Open Access
Antibacterials with Novel Chemical Scaffolds in Clinical Development
Publication type: Journal Article
Publication date: 2025-01-23
scimago Q1
wos Q1
SJR: 3.362
CiteScore: 26.2
Impact factor: 14.4
ISSN: 00126667, 11791950
Abstract
The rise of antimicrobial resistance represents a significant global health threat, driven by the diminishing efficacy of existing antibiotics, a lack of novel antibacterials entering the market, and an over- or misuse of existing antibiotics, which accelerates the evolution of resistant bacterial strains. This review focuses on innovative therapies by highlighting 19 novel antibacterials in clinical development as of June 2024. These selected compounds are characterized by new chemical scaffolds, novel molecular targets, and/or unique mechanisms of action, which render their potential to break antimicrobial resistance particularly high. A detailed analysis of the scientific foundations behind each of these compounds is provided, including their pharmacodynamic profiles, current development state, and potential for overcoming existing limitations in antibiotic therapy. By presenting this subset of chemically novel antibacterials, the review highlights the ability to innovate in antibiotic drug development to counteract bacterial resistance and improve treatment outcomes.
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Metrics
10
Total citations:
10
Citations from 2024:
9
(90%)
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RIS |
BibTex |
MLA
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GOST
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Heimann D. et al. Antibacterials with Novel Chemical Scaffolds in Clinical Development // Drugs. 2025. Vol. 85. No. 3. pp. 293-323.
GOST all authors (up to 50)
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Heimann D., Kohnhäuser D., Kohnhäuser A. J., Brönstrup M. Antibacterials with Novel Chemical Scaffolds in Clinical Development // Drugs. 2025. Vol. 85. No. 3. pp. 293-323.
Cite this
RIS
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TY - JOUR
DO - 10.1007/s40265-024-02137-x
UR - https://link.springer.com/10.1007/s40265-024-02137-x
TI - Antibacterials with Novel Chemical Scaffolds in Clinical Development
T2 - Drugs
AU - Heimann, Dominik
AU - Kohnhäuser, Daniel
AU - Kohnhäuser, Alexandra Jana
AU - Brönstrup, Mark
PY - 2025
DA - 2025/01/23
PB - Springer Nature
SP - 293-323
IS - 3
VL - 85
SN - 0012-6667
SN - 1179-1950
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2025_Heimann,
author = {Dominik Heimann and Daniel Kohnhäuser and Alexandra Jana Kohnhäuser and Mark Brönstrup},
title = {Antibacterials with Novel Chemical Scaffolds in Clinical Development},
journal = {Drugs},
year = {2025},
volume = {85},
publisher = {Springer Nature},
month = {jan},
url = {https://link.springer.com/10.1007/s40265-024-02137-x},
number = {3},
pages = {293--323},
doi = {10.1007/s40265-024-02137-x}
}
Cite this
MLA
Copy
Heimann, Dominik, et al. “Antibacterials with Novel Chemical Scaffolds in Clinical Development.” Drugs, vol. 85, no. 3, Jan. 2025, pp. 293-323. https://link.springer.com/10.1007/s40265-024-02137-x.
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