Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines
Ivan A Yaremenko
1, 2
,
Mikhail A Syroeshkin
1
,
Dmitri O. Levitsky
2, 3
,
Fabrice Fleury
3
,
Alexander O. Terent’ev
1, 2
1
Publication type: Journal Article
Publication date: 2016-11-09
scimago Q2
wos Q3
SJR: 0.470
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Abstract
Synthetic ozonides and tetraoxanes were shown to have high cytotoxicity in vitro when tested on androgen-independent prostate cancer cell lines DU145 and PC3, which is in some cases was higher than that of doxorubicin, cisplatin, etoposide, artemisinin, and artesunate. Activity of ozonide stereoisomers differs from each other. This difference in activity and absence of correlation between activity of stereoisomers and their oxidative properties allow us to suggest existence of a quite specific mechanism of cytotoxicity of these endoperoxides different from a traditional mechanism based mainly on oxidative properties of peroxides.
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47
Total citations:
47
Citations from 2024:
9
(19.15%)
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GOST
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Yaremenko I. A. et al. Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines // Medicinal Chemistry Research. 2016. Vol. 26. No. 1. pp. 170-179.
GOST all authors (up to 50)
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Yaremenko I. A., Syroeshkin M. A., Levitsky D. O., Fleury F., Terent’ev A. O. Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines // Medicinal Chemistry Research. 2016. Vol. 26. No. 1. pp. 170-179.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s00044-016-1736-2
UR - https://doi.org/10.1007/s00044-016-1736-2
TI - Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines
T2 - Medicinal Chemistry Research
AU - Yaremenko, Ivan A
AU - Syroeshkin, Mikhail A
AU - Levitsky, Dmitri O.
AU - Fleury, Fabrice
AU - Terent’ev, Alexander O.
PY - 2016
DA - 2016/11/09
PB - Springer Nature
SP - 170-179
IS - 1
VL - 26
SN - 1054-2523
SN - 1554-8120
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Yaremenko,
author = {Ivan A Yaremenko and Mikhail A Syroeshkin and Dmitri O. Levitsky and Fabrice Fleury and Alexander O. Terent’ev},
title = {Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines},
journal = {Medicinal Chemistry Research},
year = {2016},
volume = {26},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007/s00044-016-1736-2},
number = {1},
pages = {170--179},
doi = {10.1007/s00044-016-1736-2}
}
Cite this
MLA
Copy
Yaremenko, Ivan A., et al. “Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines.” Medicinal Chemistry Research, vol. 26, no. 1, Nov. 2016, pp. 170-179. https://doi.org/10.1007/s00044-016-1736-2.
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