Tetrahedron Letters, volume 30, issue 28, pages 3703-3706

A biologically active 1,2,3-trithiane derivative from the New Zealand ascidain Aplidium sp. D.

Brent R. Copp ¹

John W Blunt ¹

Murray Munro ¹

Lewis K Pannell ²

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Department of Chemistry, University of Canterbury Christchurch, New Zealand |

National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA |

Publication type: Journal Article

Publication date: 1989-01-01

Elsevier

Journal: Tetrahedron Letters

scimago Q3

wos Q3

SJR: 0.323

CiteScore: 3.5

Impact factor: 1.5

ISSN: 00404039, 18733581

DOI: 10.1016/S0040-4039(01)80488-3

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Organic Chemistry

Drug Discovery

Biochemistry

Abstract

cis -5-Hydroxy-4-(4′-hydroxy-3′-methoxyphenyl)-4-(2″-imidazolyl)-1,2,3-trithiane 1 was isolated from the New Zealand ascidian Aplidium sp. D. In neutral or slightly basic solution 1 interconverts to the trans isomer 3 . These isomers are the precursors to 2-vanilloyl imidazole 2 , previously reported from an extract of an Australian species of Aplidium . Both trithiane isomers are active against P388 leukemia cells in vitro .

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52 Total citations

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GOST Copy

Copp B. R. et al. A biologically active 1,2,3-trithiane derivative from the New Zealand ascidain Aplidium sp. D. // Tetrahedron Letters. 1989. Vol. 30. No. 28. pp. 3703-3706.

GOST all authors (up to 50) Copy

Copp B. R., Blunt J. W., Munro M., Pannell L. K. A biologically active 1,2,3-trithiane derivative from the New Zealand ascidain Aplidium sp. D. // Tetrahedron Letters. 1989. Vol. 30. No. 28. pp. 3703-3706.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/S0040-4039(01)80488-3

UR - https://doi.org/10.1016/S0040-4039(01)80488-3

TI - A biologically active 1,2,3-trithiane derivative from the New Zealand ascidain Aplidium sp. D.

T2 - Tetrahedron Letters

AU - Copp, Brent R.

AU - Blunt, John W

AU - Munro, Murray

AU - Pannell, Lewis K

PY - 1989

DA - 1989/01/01

PB - Elsevier

SP - 3703-3706

IS - 28

VL - 30

SN - 0040-4039

SN - 1873-3581

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{1989_Copp,

author = {Brent R. Copp and John W Blunt and Murray Munro and Lewis K Pannell},

title = {A biologically active 1,2,3-trithiane derivative from the New Zealand ascidain Aplidium sp. D.},

journal = {Tetrahedron Letters},

year = {1989},

volume = {30},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016/S0040-4039(01)80488-3},

number = {28},

pages = {3703--3706},

doi = {10.1016/S0040-4039(01)80488-3}

}

MLA

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MLA Copy

Copp, Brent R., et al. “A biologically active 1,2,3-trithiane derivative from the New Zealand ascidain Aplidium sp. D..” Tetrahedron Letters, vol. 30, no. 28, Jan. 1989, pp. 3703-3706. https://doi.org/10.1016/S0040-4039(01)80488-3.

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Publisher

Elsevier

Journal

Tetrahedron Letters

scimago Q3

wos Q3

SJR

0.323

CiteScore

3.5

Impact factor

1.5

ISSN

00404039 (Print)

18733581 (Electronic)