Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology
Rui Huang
1
,
Yiwen Shen
1
,
Ying-Yun Guan
2
,
Yi-Xin Jiang
1
,
Ye Wu
1
,
Khalid Rahman
3
,
Li-Jun Zhang
1
,
Haijun Liu
4
,
Xin Luan
1
Publication type: Journal Article
Publication date: 2020-10-01
scimago Q1
wos Q1
SJR: 2.007
CiteScore: 17.8
Impact factor: 9.6
ISSN: 17427061, 18787568
PubMed ID:
32911102
Biochemistry
Molecular Biology
General Medicine
Biotechnology
Biomaterials
Biomedical Engineering
Abstract
Mesoporous silica nanoparticles (MSNs) have received increasing interest due to their tunable particle size, large surface area, stable framework, and easy surface modification. They are increasingly being used in varying applications as delivery vehicles including bio-imaging, drug delivery, biosensors and tissue engineering etc. Precise structure control and the ability to modify surface properties of MSNs are important for their applications. This review summarises the different synthetic methods for the preparation of well-ordered MSNs with tunable pore volume as well as the approaches of drugs loading, especially highlighting the facile surface functionalization for various purposes and versatile biomedical applications in oncology. Finally, the challenges of clinical transformation of MSNs-based nanomedicines are further discussed.
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Metrics
125
Total citations:
125
Citations from 2024:
46
(36.8%)
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GOST
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Huang R. et al. Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology // Acta Biomaterialia. 2020. Vol. 116. pp. 1-15.
GOST all authors (up to 50)
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Huang R., Shen Y., Guan Y., Jiang Y., Wu Y., Rahman K., Zhang L., Liu H., Luan X. Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology // Acta Biomaterialia. 2020. Vol. 116. pp. 1-15.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.actbio.2020.09.009
UR - https://doi.org/10.1016/j.actbio.2020.09.009
TI - Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology
T2 - Acta Biomaterialia
AU - Huang, Rui
AU - Shen, Yiwen
AU - Guan, Ying-Yun
AU - Jiang, Yi-Xin
AU - Wu, Ye
AU - Rahman, Khalid
AU - Zhang, Li-Jun
AU - Liu, Haijun
AU - Luan, Xin
PY - 2020
DA - 2020/10/01
PB - Elsevier
SP - 1-15
VL - 116
PMID - 32911102
SN - 1742-7061
SN - 1878-7568
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Huang,
author = {Rui Huang and Yiwen Shen and Ying-Yun Guan and Yi-Xin Jiang and Ye Wu and Khalid Rahman and Li-Jun Zhang and Haijun Liu and Xin Luan},
title = {Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology},
journal = {Acta Biomaterialia},
year = {2020},
volume = {116},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.actbio.2020.09.009},
pages = {1--15},
doi = {10.1016/j.actbio.2020.09.009}
}