Bioorganic and Medicinal Chemistry Letters

, том 19 , издание 2 , страницы 390-392

A novel sesquiterpene quinone from Hainan sponge Dysidea villosa

Yan Li ¹

Yu Zhang ¹

Xu Shen ¹

Yue-Wei Guo ¹

Скрыть аффилиации авторов Показать аффилиации авторов: 1 аффилиация

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China. |

Тип публикации: Journal Article

Дата публикации: 2009-01-01

Elsevier

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

БС2

SJR: 0.472

CiteScore: 5.1

Impact factor: 2.2

ISSN: 0960894X, 14643405

DOI: 10.1016/j.bmcl.2008.11.068

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PubMed ID: 19091557

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Краткое описание

A new sesquiterpene quinone, 21-dehydroxybolinaquinone (5), together with two known related analogues, bolinaquinone (6) and dysidine (7), had been isolated from the Hainan sponge Dysidea villosa. The structure of the new compound 5 was elucidated on the basis of detailed analysis of spectroscopic data and by comparison with related model compounds. Compounds 5-7 were evaluated for the inhibitory activity against hPTP1B, a potential drug target for treatment of type-II diabetes and obesity, and cytotoxic activity against Hela cell line. The results showed that dysidine (7) had the strongest hPTP1B inhibitory activity with an IC(50) value of 6.70microM and 6 had significant cytotoxic activity against Hela cell line with an IC(50) value of 5.45microM. New compound 5 showed moderate PTP1B inhibitory activity and cytotoxicity with IC(50) values of 39.50 and 19.45microM, respectively.

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Li Y. et al. A novel sesquiterpene quinone from Hainan sponge Dysidea villosa // Bioorganic and Medicinal Chemistry Letters. 2009. Vol. 19. No. 2. pp. 390-392.

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Li Y., Zhang Yu., Shen X., Guo Y. A novel sesquiterpene quinone from Hainan sponge Dysidea villosa // Bioorganic and Medicinal Chemistry Letters. 2009. Vol. 19. No. 2. pp. 390-392.

RIS |

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TY - JOUR

DO - 10.1016/j.bmcl.2008.11.068

UR - https://doi.org/10.1016/j.bmcl.2008.11.068

TI - A novel sesquiterpene quinone from Hainan sponge Dysidea villosa

T2 - Bioorganic and Medicinal Chemistry Letters

AU - Li, Yan

AU - Zhang, Yu

AU - Shen, Xu

AU - Guo, Yue-Wei

PY - 2009

DA - 2009/01/01

PB - Elsevier

SP - 390-392

IS - 2

VL - 19

PMID - 19091557

SN - 0960-894X

SN - 1464-3405

ER -

BibTex |

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@article{2009_Li,

author = {Yan Li and Yu Zhang and Xu Shen and Yue-Wei Guo},

title = {A novel sesquiterpene quinone from Hainan sponge Dysidea villosa},

journal = {Bioorganic and Medicinal Chemistry Letters},

year = {2009},

volume = {19},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016/j.bmcl.2008.11.068},

number = {2},

pages = {390--392},

doi = {10.1016/j.bmcl.2008.11.068}

}

MLA

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MLA Скопировать

Li, Yan, et al. “A novel sesquiterpene quinone from Hainan sponge Dysidea villosa.” Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 2, Jan. 2009, pp. 390-392. https://doi.org/10.1016/j.bmcl.2008.11.068.

Издатель

Elsevier

Журнал

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

БС2

SJR

0.472

CiteScore

5.1

Impact factor

2.2

ISSN

0960894X (Print)

14643405 (Electronic)