Optical control of Class A G protein-coupled receptors with photoswitchable ligands
Publication type: Journal Article
Publication date: 2022-04-01
scimago Q1
wos Q1
SJR: 1.304
CiteScore: 10.3
Impact factor: 4.2
ISSN: 14714892, 14714973
PubMed ID:
35255451
Drug Discovery
Pharmacology
Abstract
The field of photopharmacology of Class A GPCR ligands has recently attracted attention. In this review we analyze 31 papers on currently available photoswitchable ligands for Class A GPCRs. Using the six most recurring terms of all combined paper abstracts, one can extract the overarching goal of this area of research: "Photoswitchable ligands control receptor activity with light" (represented in the TOC graphic). We analyze the design, photochemistry and pharmacology of the photoswitchable ligands. Trends, challenges and limitations will be discussed. A number of efficient photoswitchable ligands that allow optical modulation of GPCR function in various in vitro assays are presented. Moreover, optical modulation of in vivo GPCR function is within reach and the first reports to this end are highlighted.
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Metrics
39
Total citations:
39
Citations from 2024:
27
(69.23%)
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BibTex
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GOST
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Wijtmans M. et al. Optical control of Class A G protein-coupled receptors with photoswitchable ligands // Current Opinion in Pharmacology. 2022. Vol. 63. p. 102192.
GOST all authors (up to 50)
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Wijtmans M., Josimovic I., Vischer H. F., LEURS R. Optical control of Class A G protein-coupled receptors with photoswitchable ligands // Current Opinion in Pharmacology. 2022. Vol. 63. p. 102192.
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RIS
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TY - JOUR
DO - 10.1016/j.coph.2022.102192
UR - https://doi.org/10.1016/j.coph.2022.102192
TI - Optical control of Class A G protein-coupled receptors with photoswitchable ligands
T2 - Current Opinion in Pharmacology
AU - Wijtmans, Maikel
AU - Josimovic, Ivana
AU - Vischer, Henry F.
AU - LEURS, R.
PY - 2022
DA - 2022/04/01
PB - Elsevier
SP - 102192
VL - 63
PMID - 35255451
SN - 1471-4892
SN - 1471-4973
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Wijtmans,
author = {Maikel Wijtmans and Ivana Josimovic and Henry F. Vischer and R. LEURS},
title = {Optical control of Class A G protein-coupled receptors with photoswitchable ligands},
journal = {Current Opinion in Pharmacology},
year = {2022},
volume = {63},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.coph.2022.102192},
pages = {102192},
doi = {10.1016/j.coph.2022.102192}
}
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