Materials Letters

, volume 109 , pages 20-22

Targeting of coenzyme Q10 via d-alpha-tocopheryl polyethylene glycol 1000 succinate-based nanoemulsion to the heart

Huafeng Zhou ^{1, 2}

Jing Zhang ³

Qingxian Jin ⁴

GuoQing Liu ⁵

Long Yingfang ³

Mingxing Duan ³

Qiang Xia ⁵

Hide authors affiliations Show authors affiliations: 5 affiliations

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China |

State-key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China |

State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing, 100084, China. |

⁴

Henan Provincial Key Laboratory of Surface & Interface Science, Zhengzhou University of Light Industry, Zhengzhou, 450002, China. |

⁵

State key laboratory of bioelectronics, School of biological science & medical engineering, Southeast University, Nanjing, 210096, China |

Publication type: Journal Article

Publication date: 2013-10-01

Elsevier

Materials Letters

scimago Q2

wos Q3

SJR: 0.591

CiteScore: 5.4

Impact factor: 2.7

ISSN: 0167577X, 18734979

DOI: 10.1016/j.matlet.2013.07.057

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Condensed Matter Physics

General Materials Science

Mechanical Engineering

Mechanics of Materials

Abstract

d -alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS), a water-soluble derivative of natural vitamin E, has been intensively used in drug delivery systems. TPGS (CoQ10-NE-TPGS) and lecithin-based (CoQ10-NE-LC) coenzyme Q10-loaded nanoemulsions were prepared by hot high-pressure homogenization (HPH) and tested for their ability to target heart tissue. Both formulations yielded particles ~50 nm in diameter. CoQ10 in both the formulations was in a supercooled melt state without crystallization. CoQ10-NE-TPGS more effectively delivered CoQ10 to heart tissue than CoQ10-NE-LC after intravenous administration. CoQ10 concentration in the heart was 2.8-fold higher at 5 min after intravenous administration of CoQ10-NE-TPGS compared to CoQ10-NE-LC. Higher tissue levels were maintained for 90 min after injection. These data suggest that CoQ10-NE-TPGS could be a potential vehicle for rapid delivery of CoQ10 to heart tissue.

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GOST |

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GOST Copy

Zhou H. et al. Targeting of coenzyme Q10 via d-alpha-tocopheryl polyethylene glycol 1000 succinate-based nanoemulsion to the heart // Materials Letters. 2013. Vol. 109. pp. 20-22.

GOST all authors (up to 50) Copy

Zhou H., Zhang J., Jin Q., Liu G., Yingfang L., Duan M., Xia Q. Targeting of coenzyme Q10 via d-alpha-tocopheryl polyethylene glycol 1000 succinate-based nanoemulsion to the heart // Materials Letters. 2013. Vol. 109. pp. 20-22.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.matlet.2013.07.057

UR - https://doi.org/10.1016/j.matlet.2013.07.057

TI - Targeting of coenzyme Q10 via d-alpha-tocopheryl polyethylene glycol 1000 succinate-based nanoemulsion to the heart

T2 - Materials Letters

AU - Zhou, Huafeng

AU - Zhang, Jing

AU - Jin, Qingxian

AU - Liu, GuoQing

AU - Yingfang, Long

AU - Duan, Mingxing

AU - Xia, Qiang

PY - 2013

DA - 2013/10/01

PB - Elsevier

SP - 20-22

VL - 109

SN - 0167-577X

SN - 1873-4979

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2013_Zhou,

author = {Huafeng Zhou and Jing Zhang and Qingxian Jin and GuoQing Liu and Long Yingfang and Mingxing Duan and Qiang Xia},

title = {Targeting of coenzyme Q10 via d-alpha-tocopheryl polyethylene glycol 1000 succinate-based nanoemulsion to the heart},

journal = {Materials Letters},

year = {2013},

volume = {109},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016/j.matlet.2013.07.057},

pages = {20--22},

doi = {10.1016/j.matlet.2013.07.057}

}

Publisher

Elsevier

Journal

Materials Letters

scimago Q2

wos Q3

SJR

0.591

CiteScore

5.4

Impact factor

2.7

ISSN

0167577X (Print)

18734979