Open Access

Photoacoustics

, volume 34 , pages 100569

In vivo liver function reserve assessments in alcoholic liver disease by scalable photoacoustic imaging

T. Sun ^{1, 2}

Jing Lv ^{2, 3}

Xingyang Zhao ²

Wenya Li ²

Zhenhui Zhang ¹

Liming Nie ²

Hide authors affiliations Show authors affiliations: 3 affiliations

Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China |

Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, China |

Guangdong Cardiovascular Institute, Guangzhou 510080, China |

Publication type: Journal Article

Publication date: 2023-12-01

Elsevier

Photoacoustics

scimago Q1

wos Q1

SJR: 1.651

CiteScore: 13.7

Impact factor: 6.8

ISSN: 22135979

DOI: 10.1016/j.pacs.2023.100569

Copy DOI

PubMed ID: 38046637

Atomic and Molecular Physics, and Optics

Radiology, Nuclear Medicine and imaging

Abstract

We present a rapid and high-resolution photoacoustic imaging method for evaluating the liver function reserve (LFR). To validate its accuracy, we establish alcoholic liver disease (ALD) models and employ dual-wavelength spectral unmixing to assess oxygen metabolism. An empirical mathematical model fits the photoacoustic signals, obtaining liver metabolism curve and LFR parameters. Liver oxygen metabolism significantly drops in ALD with the emergence of abnormal hepatic lobular structure. ICG half-life remarkably extends from 241 to 568 s in ALD. A significant decline in LFR occurs in terminal region compared to central region, indicated by a 106.9 s delay in ICG half-life, likely due to hepatic artery and vein damage causing hypoxia and inadequate nutrition. Reduced glutathione repairs LFR with a 43% improvement by reducing alcohol-induced oxidative damage. Scalable photoacoustic imaging shows immense potential for assessing LFR in alcoholic-related diseases, providing assistance to early detection and management of liver disease.

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Cite this

GOST |

Cite this

GOST Copy

Sun T. et al. In vivo liver function reserve assessments in alcoholic liver disease by scalable photoacoustic imaging // Photoacoustics. 2023. Vol. 34. p. 100569.

GOST all authors (up to 50) Copy

Sun T., Lv J., Zhao X., Li W., Zhang Z., Nie L. In vivo liver function reserve assessments in alcoholic liver disease by scalable photoacoustic imaging // Photoacoustics. 2023. Vol. 34. p. 100569.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.pacs.2023.100569

UR - https://doi.org/10.1016/j.pacs.2023.100569

TI - In vivo liver function reserve assessments in alcoholic liver disease by scalable photoacoustic imaging

T2 - Photoacoustics

AU - Sun, T.

AU - Lv, Jing

AU - Zhao, Xingyang

AU - Li, Wenya

AU - Zhang, Zhenhui

AU - Nie, Liming

PY - 2023

DA - 2023/12/01

PB - Elsevier

SP - 100569

VL - 34

PMID - 38046637

SN - 2213-5979

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2023_Sun,

author = {T. Sun and Jing Lv and Xingyang Zhao and Wenya Li and Zhenhui Zhang and Liming Nie},

title = {In vivo liver function reserve assessments in alcoholic liver disease by scalable photoacoustic imaging},

journal = {Photoacoustics},

year = {2023},

volume = {34},

publisher = {Elsevier},

month = {dec},

url = {https://doi.org/10.1016/j.pacs.2023.100569},

pages = {100569},

doi = {10.1016/j.pacs.2023.100569}

}

Publisher

Elsevier

Journal

Photoacoustics

scimago Q1

wos Q1

SJR

1.651

CiteScore

13.7

Impact factor

6.8

ISSN

22135979 (Print)

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