Pharmaceutical applications of silk sericin

Silk sericin is an applicable protein extracted from dried silk cocoons, which are composed of a polar amino acid chain with hydroxyl, carboxyl, and amino functional groups. It anticipated that the functionality present in sericin provides excellent assets such as stability, release-modifying capacity, interaction with molecules, etc. It has various significant properties like biocompatibility, biodegradability, non-toxicity, hydrophilicity, etc. Besides, sericin exhibits the capability to form gels, nanoparticles, micro-particles, and keen bioengineered materials. Sericin also offers stability by strong affinity to the drug substance/molecules. Currently, sericin reconnoitered for a variety of pharmaceutical applications including solubility enhancement, release modifications, formulation stabilization, and as a drug carrier, etc. The focus of the review is to deliver an impression of the sericin based pharmaceutical applications including nanocrystal and nanoparticle stabilization, inhibition of devitrification, solubility enhancement, controlled and the extended-release formulation, targeted drug delivery, wound healing applications and as a suitable carrier.