Minor oxygenated cannabinoids from high potency Cannabis sativa L.
Publication type: Journal Article
Publication date: 2015-09-01
scimago Q1
wos Q1
SJR: 0.726
CiteScore: 6.9
Impact factor: 3.4
ISSN: 00319422, 18733700
PubMed ID:
26093324
Biochemistry
Molecular Biology
General Medicine
Plant Science
Horticulture
Abstract
Nine oxygenated cannabinoids were isolated from a high potency Cannabis sativa L. variety. Structure elucidation was achieved using spectroscopic techniques, including 1D and 2D NMR, HRMS and GC-MS. These minor compounds include four hexahydrocannabinols, four tetrahydrocannabinols, and one hydroxylated cannabinol, namely 9α-hydroxyhexahydrocannabinol, 7-oxo-9α-hydroxyhexa-hydrocannabinol, 10α-hydroxyhexahydrocannabinol, 10aR-hydroxyhexahydrocannabinol, Δ(9)-THC aldehyde A, 8-oxo-Δ(9)-THC, 10aα-hydroxy-10-oxo-Δ(8)-THC, 9α-hydroxy-10-oxo-Δ(6a,10a)-THC, and 1'S-hydroxycannabinol, respectively. The latter compound showed moderate anti-MRSa (IC50 10.0 μg/mL), moderate antileishmanial (IC50 14.0 μg/mL) and mild antimalarial activity against Plasmodium falciparum (D6 clone) and P. falciparum (W2 clone) with IC50 values of 3.4 and 2.3 μg/mL, respectively.
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Total citations:
78
Citations from 2024:
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(25.64%)
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Ahmed S. A. et al. Minor oxygenated cannabinoids from high potency Cannabis sativa L. // Phytochemistry. 2015. Vol. 117. pp. 194-199.
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Ahmed S. A., Ross S. A., Slade D., Radwan M. M., ElSohly M. Minor oxygenated cannabinoids from high potency Cannabis sativa L. // Phytochemistry. 2015. Vol. 117. pp. 194-199.
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TY - JOUR
DO - 10.1016/j.phytochem.2015.04.007
UR - https://doi.org/10.1016/j.phytochem.2015.04.007
TI - Minor oxygenated cannabinoids from high potency Cannabis sativa L.
T2 - Phytochemistry
AU - Ahmed, Safwat A.
AU - Ross, Samir A
AU - Slade, Desmond
AU - Radwan, Mohamed M.
AU - ElSohly, M
PY - 2015
DA - 2015/09/01
PB - Elsevier
SP - 194-199
VL - 117
PMID - 26093324
SN - 0031-9422
SN - 1873-3700
ER -
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BibTex (up to 50 authors)
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@article{2015_Ahmed,
author = {Safwat A. Ahmed and Samir A Ross and Desmond Slade and Mohamed M. Radwan and M ElSohly},
title = {Minor oxygenated cannabinoids from high potency Cannabis sativa L.},
journal = {Phytochemistry},
year = {2015},
volume = {117},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.phytochem.2015.04.007},
pages = {194--199},
doi = {10.1016/j.phytochem.2015.04.007}
}