Fabrication and characterization of the stable Ag-Au-metal-organic-frameworks: An application for sensitive detection of thiabendazole

Thiabendazole is likely to cause thyroid hormone imbalances and liver damage at high doses. Conventional detection methods are time-consuming with cumbersome pretreatment or insufficient sensitivity. Herein, Metal-organic framework (MOF, Mil-101(Fe))modified with inositol hexaphosphate (IP6)is fabricated by a solvothermal method and thenAg-Au-IP6-Mil-101(Fe) is obtained by in original position of MOF surface with the aid of IP6. The as-prepared Ag-Au-IP6-Mil-101(Fe) substrate exhibits high stability. Certain target molecules containing atoms of N or S could access the proximity to the surface of Au-IP6-Mil-101(Fe) substrate by the strong interaction with Fe3+ in the MOF, leading to improvement of SERS detection sensitivity. As a real application, Ag-Au-IP6-Mil-101 based Raman strategy is developed to achieve rapid detection of thiabendazole in juice and has good linearity in the range of 1.5 ppm˜75 ppm with correlation coefficient (R2) of 0.986. The detection limit for TBZ reached 50 ppb in juice sample, which meets the requirement of the national standard. In addition, the Ag-Au-IP6-Mil-101(Fe)substrate possessing peroxidase-like activity could degrade organic dyes within a short time.