The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles
Publication type: Journal Article
Publication date: 1989-12-04
scimago Q1
wos Q2
SJR: 1.222
CiteScore: 6.1
Impact factor: 3.0
ISSN: 00145793, 18733468
PubMed ID:
2599097
Biochemistry
Molecular Biology
Cell Biology
Genetics
Structural Biology
Biophysics
Abstract
It has been suggested to use surfactant micelles as microcontainers for increasing the efficiency of neuroleptic targeting from blood flow into the brain. The neuroleptic action of haloperidol, intraperitoneally injected into mice in micellar solution of non‐ionic block copolymer surfactant (pluronic P‐85) in water, increased several‐fold if compared with that observed for haloperidol aqueous solution. Incorporation of brain‐specific antibodies into haloperidol‐containing micelles resulted in additional drastic increase (more than by 2 orders of magnitude) in the drug effect.
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241
Total citations:
241
Citations from 2024:
7
(2%)
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GOST
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KABANOV A. et al. The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles // FEBS Letters. 1989. Vol. 258. No. 2. pp. 343-345.
GOST all authors (up to 50)
Copy
KABANOV A., Chekhonin V. P., Alakhov V. Yu., Batrakova E. V., Lebedev A. S., Melik-Nubarov N., Arzhakov S. A., Levashov A. V., Morozov G. V., Severin E. S., Kabanov V. The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles // FEBS Letters. 1989. Vol. 258. No. 2. pp. 343-345.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/0014-5793(89)81689-8
UR - https://febs.onlinelibrary.wiley.com/doi/10.1016/0014-5793(89)81689-8
TI - The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles
T2 - FEBS Letters
AU - KABANOV, A.V.
AU - Chekhonin, V. P.
AU - Alakhov, V Yu
AU - Batrakova, E V
AU - Lebedev, A. S.
AU - Melik-Nubarov, N.S.
AU - Arzhakov, S A
AU - Levashov, A V
AU - Morozov, G V
AU - Severin, E S.
AU - Kabanov, V.A.
PY - 1989
DA - 1989/12/04
PB - Wiley
SP - 343-345
IS - 2
VL - 258
PMID - 2599097
SN - 0014-5793
SN - 1873-3468
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1989_KABANOV,
author = {A.V. KABANOV and V. P. Chekhonin and V Yu Alakhov and E V Batrakova and A. S. Lebedev and N.S. Melik-Nubarov and S A Arzhakov and A V Levashov and G V Morozov and E S. Severin and V.A. Kabanov},
title = {The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles},
journal = {FEBS Letters},
year = {1989},
volume = {258},
publisher = {Wiley},
month = {dec},
url = {https://febs.onlinelibrary.wiley.com/doi/10.1016/0014-5793(89)81689-8},
number = {2},
pages = {343--345},
doi = {10.1016/0014-5793(89)81689-8}
}
Cite this
MLA
Copy
KABANOV, A.V., et al. “The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles.” FEBS Letters, vol. 258, no. 2, Dec. 1989, pp. 343-345. https://febs.onlinelibrary.wiley.com/doi/10.1016/0014-5793(89)81689-8.
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