Colchicine intoxication: Clinical pharmacology, risk factors, features, and management
Publication type: Journal Article
Publication date: 1991-12-01
scimago Q1
wos Q1
SJR: 1.874
CiteScore: 8.1
Impact factor: 4.4
ISSN: 00490172, 1532866X
PubMed ID:
1788551
Rheumatology
Anesthesiology and Pain Medicine
Abstract
The use of colchicine for acute gouty arthritis dates to ancient times. In recent years, colchicine also has been used successfully for various other rheumatic and nonrheumatic conditions. Colchicine is a safe drug when used according to established therapeutic guidelines. However, toxicity can be considerable if ingested intentionally or if the recommended doses are exceeded. Colchicine intoxication is characterized by multi-organ involvement and by the poor prognosis associated with administration of large amounts of the drug. Therapy is basically supportive and symptomatic because of the rapid distribution and binding of colchicine to the affected tissues. Use of anticolchicine antibodies is a novel approach that has shown promise in experimental models. Important research questions pertain to the effect of liver and kidney disease on colchicine metabolism, use of colchicine levels in the diagnosis of intoxication and for prognostication, and application of immunotoxicotherapy for colchicine poisoning in humans.
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Metrics
118
Total citations:
118
Citations from 2024:
7
(5.93%)
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MLA
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GOST
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Putterman C. et al. Colchicine intoxication: Clinical pharmacology, risk factors, features, and management // Seminars in Arthritis and Rheumatism. 1991. Vol. 21. No. 3. pp. 143-155.
GOST all authors (up to 50)
Copy
Putterman C., Ben-Chetrit E., Caraco Y., Levy M. Colchicine intoxication: Clinical pharmacology, risk factors, features, and management // Seminars in Arthritis and Rheumatism. 1991. Vol. 21. No. 3. pp. 143-155.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/0049-0172(91)90003-i
UR - https://doi.org/10.1016/0049-0172(91)90003-i
TI - Colchicine intoxication: Clinical pharmacology, risk factors, features, and management
T2 - Seminars in Arthritis and Rheumatism
AU - Putterman, C.
AU - Ben-Chetrit, Eldad
AU - Caraco, Y.
AU - Levy, Micha
PY - 1991
DA - 1991/12/01
PB - Elsevier
SP - 143-155
IS - 3
VL - 21
PMID - 1788551
SN - 0049-0172
SN - 1532-866X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1991_Putterman,
author = {C. Putterman and Eldad Ben-Chetrit and Y. Caraco and Micha Levy},
title = {Colchicine intoxication: Clinical pharmacology, risk factors, features, and management},
journal = {Seminars in Arthritis and Rheumatism},
year = {1991},
volume = {21},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/0049-0172(91)90003-i},
number = {3},
pages = {143--155},
doi = {10.1016/0049-0172(91)90003-i}
}
Cite this
MLA
Copy
Putterman, C., et al. “Colchicine intoxication: Clinical pharmacology, risk factors, features, and management.” Seminars in Arthritis and Rheumatism, vol. 21, no. 3, Dec. 1991, pp. 143-155. https://doi.org/10.1016/0049-0172(91)90003-i.