Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin
Тип публикации: Journal Article
Дата публикации: 1993-01-01
scimago Q2
wos Q3
БС2
SJR: 0.694
CiteScore: 4.4
Impact factor: 2
ISSN: 09201211, 18726844
PubMed ID:
8383597
Neurology
Neurology (clinical)
Краткое описание
3-Isobutyl GABA is a derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and is also structurally related to the novel anticonvulsant gabapentin. The S(+) enantiomer of 3-isobutyl GABA blocks maximal electroshock seizures in mice and also potently displaces tritiated gabapentin from a novel high-affinity binding site in rat brain membrane fractions. The R(-) enantiomer is much less active in both assays, suggesting that the gabapentin binding site is involved in the anticonvulsant activity of 3-isobutyl GABA.
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Метрики
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Всего цитирований:
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ГОСТ
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Charles H. Taylor C. A. et al. Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin // Epilepsy Research. 1993. Vol. 14. No. 1. pp. 11-15.
ГОСТ со всеми авторами (до 50)
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Charles H. Taylor C. A., Vartanian M. G., YUEN P., Bigge C., Suman Chauhan N., Hill D. E. Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin // Epilepsy Research. 1993. Vol. 14. No. 1. pp. 11-15.
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RIS
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TY - JOUR
DO - 10.1016/0920-1211(93)90070-N
UR - https://doi.org/10.1016/0920-1211(93)90070-N
TI - Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin
T2 - Epilepsy Research
AU - Charles H. Taylor, Charles A.
AU - Vartanian, Mark G
AU - YUEN, Po-wai
AU - Bigge, Christopher
AU - Suman Chauhan, N
AU - Hill, D. E.
PY - 1993
DA - 1993/01/01
PB - Elsevier
SP - 11-15
IS - 1
VL - 14
PMID - 8383597
SN - 0920-1211
SN - 1872-6844
ER -
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BibTex (до 50 авторов)
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@article{1993_Charles H. Taylor,
author = {Charles A. Charles H. Taylor and Mark G Vartanian and Po-wai YUEN and Christopher Bigge and N Suman Chauhan and D. E. Hill},
title = {Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin},
journal = {Epilepsy Research},
year = {1993},
volume = {14},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/0920-1211(93)90070-N},
number = {1},
pages = {11--15},
doi = {10.1016/0920-1211(93)90070-N}
}
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MLA
Скопировать
Charles H. Taylor, Charles A., et al. “Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin.” Epilepsy Research, vol. 14, no. 1, Jan. 1993, pp. 11-15. https://doi.org/10.1016/0920-1211(93)90070-N.