Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers
Publication type: Journal Article
Publication date: 1999-03-05
scimago Q1
wos Q2
SJR: 1.222
CiteScore: 6.1
Impact factor: 3.0
ISSN: 00145793, 18733468
PubMed ID:
10100641
Biochemistry
Molecular Biology
Cell Biology
Genetics
Structural Biology
Biophysics
Abstract
Ethylene oxide and propylene oxide block copolymers (pluronics) are widely known as agents that promote drug penetration across biological barriers. We have studied the interaction of normal and malignant blood cells with pluronics L61 and P85 that have different hydrophobicity. SP2/0 myeloma cells accumulated pluronics while normal cells adsorb most of the polymer on the surface. Interaction of pluronics with cells resulted in drastic changes of membrane microviscosity. Tumor cell membrane microviscosity decreased after pluronics adsorption, in contrast to normal cells, whose membrane microviscosity was enhanced. We suppose that sensitivity of tumor cell membrane microviscosity to the pluronics action correlates with its permeability for molecular substances.
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Metrics
86
Total citations:
86
Citations from 2024:
2
(2.33%)
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MLA
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GOST
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Melik-Nubarov N. et al. Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers // FEBS Letters. 1999. Vol. 446. No. 1. pp. 194-198.
GOST all authors (up to 50)
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Melik-Nubarov N., Pomaz O. O., Dorodnych T. Yu., Badun G., Ksenofontov A. L., Schemchukova O. B., Arzhakov S. A. Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers // FEBS Letters. 1999. Vol. 446. No. 1. pp. 194-198.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/S0014-5793(99)00208-2
UR - https://febs.onlinelibrary.wiley.com/doi/10.1016/S0014-5793(99)00208-2
TI - Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers
T2 - FEBS Letters
AU - Melik-Nubarov, N.S.
AU - Pomaz, O O
AU - Dorodnych, T Yu
AU - Badun, G.A.
AU - Ksenofontov, A. L.
AU - Schemchukova, O B
AU - Arzhakov, S A
PY - 1999
DA - 1999/03/05
PB - Wiley
SP - 194-198
IS - 1
VL - 446
PMID - 10100641
SN - 0014-5793
SN - 1873-3468
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1999_Melik-Nubarov,
author = {N.S. Melik-Nubarov and O O Pomaz and T Yu Dorodnych and G.A. Badun and A. L. Ksenofontov and O B Schemchukova and S A Arzhakov},
title = {Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers},
journal = {FEBS Letters},
year = {1999},
volume = {446},
publisher = {Wiley},
month = {mar},
url = {https://febs.onlinelibrary.wiley.com/doi/10.1016/S0014-5793(99)00208-2},
number = {1},
pages = {194--198},
doi = {10.1016/S0014-5793(99)00208-2}
}
Cite this
MLA
Copy
Melik-Nubarov, N.S., et al. “Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers.” FEBS Letters, vol. 446, no. 1, Mar. 1999, pp. 194-198. https://febs.onlinelibrary.wiley.com/doi/10.1016/S0014-5793(99)00208-2.