Laboratory of Radionuclides and Labeled Compounds

In the laboratory of radionuclides and labeled compounds (Head, PhD, Badun G.A.) Work is actively underway on the study of atomic tritium reactions and the production of tritium-labeled compounds, which are used to study various physico-chemical and biochemical processes. It was possible to optimize the conditions for the production of many organic compounds, and methods for introducing tritium into biological macromolecules and complex mixtures of natural compounds were found without changing their structure and physico-chemical characteristics. The laboratory has developed and actively applies an integrated approach to the study of intermolecular interactions of proteins with various organic ligands, including drugs, surfactants, synthetic and natural polymers. Such an integrated approach is called the "tritium probe" and includes the following stages of work: obtaining a tritium-labeled substance and using it as a radioactive indicator to determine the conditions for the formation and composition of molecular complexes and mixed adsorption layers; atomic tritium treatment of the object under study; analysis of the distribution of tritium by components; determination of the structure of the object under study based on the distribution of tritium, as well as data from other methods and computer modeling. The laboratory conducts research on the adsorption modification of carbon nanoparticles and the use of such complexes in medicine. Thanks to scientific cooperation with other departments, it is possible to conduct comprehensive research, including mathematical modeling of the processes under consideration, determination of the main physico-chemical parameters in in vitro experiments, application of the results obtained in in vivo experiments both on cell cultures and on laboratory animals.