Open Access
A novel method for encapsulation of poorly water-soluble drugs: precipitation in polyelectrolyte multilayer shells
Тип публикации: Journal Article
Дата публикации: 2002-08-26
SCImago Q1
WOS Q1
БС1
SJR: 0.977
CiteScore: 9.5
Impact factor: 6
ISSN: 03785173, 18733476
PubMed ID:
12176250
Pharmaceutical Science
Краткое описание
A novel method to include poorly water-soluble substances into the polyelectrolyte capsules of defined size, stability, composition and affinity properties is proposed. Encapsulation explores the polarity gradient across the capsule wall. Capsules creation makes use of electrostatic interaction and can involve many substances as layer constituents, such as synthetic polyelectrolytes, proteins, nucleic acids, lipids and multivalent dyes. Using capsules made of synthetic polyelectrolytes as a model system was demonstrated how to prepare, to measure and to use this gradient for low molecular weigh materials encapsulation.
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ГОСТ
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Radtchenko I. L., Sukhorukov G. B., Möhwald H. A novel method for encapsulation of poorly water-soluble drugs: precipitation in polyelectrolyte multilayer shells // International Journal of Pharmaceutics. 2002. Vol. 242. No. 1-2. pp. 219-223.
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Radtchenko I. L., Sukhorukov G. B., Möhwald H. A novel method for encapsulation of poorly water-soluble drugs: precipitation in polyelectrolyte multilayer shells // International Journal of Pharmaceutics. 2002. Vol. 242. No. 1-2. pp. 219-223.
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RIS
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TY - JOUR
DO - 10.1016/S0378-5173(02)00161-8
UR - https://doi.org/10.1016/S0378-5173(02)00161-8
TI - A novel method for encapsulation of poorly water-soluble drugs: precipitation in polyelectrolyte multilayer shells
T2 - International Journal of Pharmaceutics
AU - Radtchenko, Igor L
AU - Sukhorukov, Gleb B.
AU - Möhwald, Helmuth
PY - 2002
DA - 2002/08/26
PB - Elsevier
SP - 219-223
IS - 1-2
VL - 242
PMID - 12176250
SN - 0378-5173
SN - 1873-3476
ER -
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BibTex (до 50 авторов)
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@article{2002_Radtchenko,
author = {Igor L Radtchenko and Gleb B. Sukhorukov and Helmuth Möhwald},
title = {A novel method for encapsulation of poorly water-soluble drugs: precipitation in polyelectrolyte multilayer shells},
journal = {International Journal of Pharmaceutics},
year = {2002},
volume = {242},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/S0378-5173(02)00161-8},
number = {1-2},
pages = {219--223},
doi = {10.1016/S0378-5173(02)00161-8}
}
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MLA
Скопировать
Radtchenko, Igor L., et al. “A novel method for encapsulation of poorly water-soluble drugs: precipitation in polyelectrolyte multilayer shells.” International Journal of Pharmaceutics, vol. 242, no. 1-2, Aug. 2002, pp. 219-223. https://doi.org/10.1016/S0378-5173(02)00161-8.
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