Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design.
Publication type: Journal Article
Publication date: 1996-12-01
PubMed ID:
9000013
Drug Discovery
Biochemistry
Molecular Biology
General Medicine
Pharmacology
Clinical Biochemistry
Molecular Medicine
Abstract
Recent data have highlighted the enigmatic role that water plays in biomolecular complexes. Water at the interface of a complex can increase the promiscuity of an interaction, yet it can also provide increased specificity and affinity. The ability to engineer water-binding sites into the interface between a drug and its target might prove useful in drug design.
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Metrics
449
Total citations:
449
Citations from 2024:
40
(8.91%)
Cite this
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Ladbury J. E. Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design. // Chemistry & Biology. 1996. Vol. 3. No. 12. pp. 973-980.
GOST all authors (up to 50)
Copy
Ladbury J. E. Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design. // Chemistry & Biology. 1996. Vol. 3. No. 12. pp. 973-980.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/S1074-5521(96)90164-7
UR - https://doi.org/10.1016/S1074-5521(96)90164-7
TI - Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design.
T2 - Chemistry & Biology
AU - Ladbury, John E.
PY - 1996
DA - 1996/12/01
PB - Elsevier
SP - 973-980
IS - 12
VL - 3
PMID - 9000013
SN - 1074-5521
SN - 1879-1301
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1996_Ladbury,
author = {John E. Ladbury},
title = {Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design.},
journal = {Chemistry & Biology},
year = {1996},
volume = {3},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/S1074-5521(96)90164-7},
number = {12},
pages = {973--980},
doi = {10.1016/S1074-5521(96)90164-7}
}
Cite this
MLA
Copy
Ladbury, John E.. “Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design..” Chemistry & Biology, vol. 3, no. 12, Dec. 1996, pp. 973-980. https://doi.org/10.1016/S1074-5521(96)90164-7.