Genotoxicity of streptonigrin: a review.
1
Laboratory of Cytogenetics and Mutagenesis, Instituto Multidisciplinario de Biología Celular (IMBICE), C.C. 403, 1900, La Plata, Argentina.
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Publication type: Journal Article
Publication date: 2001-03-01
scimago Q1
wos Q1
SJR: 1.882
CiteScore: 13.1
Impact factor: 4.2
ISSN: 13835742, 13882139
PubMed ID:
11223403
Genetics
Health, Toxicology and Mutagenesis
Abstract
Streptonigrin (SN, CAS no. 3930-19-6) is an aminoquinone antitumor antibiotic isolated from cultures of Streptomyces flocculus. This compound is a member of a group of antitumor agents which possess the aminoquinone moiety and that includes also mitomycin C, porfiromycin, actinomycin, rifamycin and geldanamycin. Because of the potential use of SN in clinical chemotherapy, the study of its genotoxicity has considerable practical significance.SN inhibits the synthesis of DNA and RNA, causes DNA strand breaks after reduction with NADH, induces unscheduled DNA synthesis and DNA adducts and inhibits topoisomerase II. At the chromosome level, this antibiotic causes chromosome damage and increases the frequency of sister-chromatid exchanges.SN cleaves DNA in cell-free systems by a mechanism that involves complexing with metal ions and autoxidation of the quinone moiety to semiquinone in the presence of NADH with production of oxygen-derived reactive species. Recent evidence strongly suggests that the clastogenic action of this compound is partially mediated by free radicals. The present review aims at summarizing past and current knowledge concerning the genotoxic effects of SN.
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122
Total citations:
122
Citations from 2025:
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(2.46%)
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GOST
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BOLZÁN A. D., Bianchi M. S. Genotoxicity of streptonigrin: a review. // Mutation Research - Reviews in Mutation Research. 2001. Vol. 488. No. 1. pp. 25-37.
GOST all authors (up to 50)
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BOLZÁN A. D., Bianchi M. S. Genotoxicity of streptonigrin: a review. // Mutation Research - Reviews in Mutation Research. 2001. Vol. 488. No. 1. pp. 25-37.
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RIS
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TY - JOUR
DO - 10.1016/S1383-5742(00)00062-4
UR - https://doi.org/10.1016/S1383-5742(00)00062-4
TI - Genotoxicity of streptonigrin: a review.
T2 - Mutation Research - Reviews in Mutation Research
AU - BOLZÁN, ALEJANDRO D.
AU - Bianchi, Martha S.
PY - 2001
DA - 2001/03/01
PB - Elsevier
SP - 25-37
IS - 1
VL - 488
PMID - 11223403
SN - 1383-5742
SN - 1388-2139
ER -
Cite this
BibTex (up to 50 authors)
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@article{2001_BOLZÁN,
author = {ALEJANDRO D. BOLZÁN and Martha S. Bianchi},
title = {Genotoxicity of streptonigrin: a review.},
journal = {Mutation Research - Reviews in Mutation Research},
year = {2001},
volume = {488},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/S1383-5742(00)00062-4},
number = {1},
pages = {25--37},
doi = {10.1016/S1383-5742(00)00062-4}
}
Cite this
MLA
Copy
BOLZÁN, ALEJANDRO D., and Martha S. Bianchi. “Genotoxicity of streptonigrin: a review..” Mutation Research - Reviews in Mutation Research, vol. 488, no. 1, Mar. 2001, pp. 25-37. https://doi.org/10.1016/S1383-5742(00)00062-4.