New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors
M. S. Drenichev
1, 2, 3
,
V. E. Oslovsky
1, 2, 3
,
Nikolay N Kurochkin
1, 2, 3
,
Pavel N. Solyev
1, 2, 3
,
V. A. Palyulin
5
,
Galina G. Karganova
4
,
Sergey N. Mikhailov
1, 2, 3
,
2
RUSSIAN ACADEMY OF SCIENCES
3
32 Vavilova str. Moscow 119991 Russia
|
Publication type: Journal Article
Publication date: 2017-03-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
28159412
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Design and development of nucleoside analogs is an established strategy in the antiviral drug discovery field. Nevertheless, for many viruses the coverage of structure-activity relationships (SAR) in the nucleoside chemical space is not sufficient. Here we present the nucleoside SAR exploration for tick-borne encephalitis virus (TBEV), a member of Flavivirus genus. Promising antiviral activity may be achieved by introduction of large hydrophobic substituents in the position 6 of adenosine or bulky silyl groups to the position 5'. Introduction of methyls to the ribose moiety does not lead to inhibition of TBEV reproduction. Possible mechanisms of action of these nucleosides include the inhibition of viral entry or interaction with TBEV non-structural protein 5 methyltransferase or RNA-dependent RNA polymerase domains.
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Total citations:
29
Citations from 2024:
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(17%)
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MLA
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GOST
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Orlov A. A. et al. New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors // Bioorganic and Medicinal Chemistry Letters. 2017. Vol. 27. No. 5. pp. 1267-1273.
GOST all authors (up to 50)
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Drenichev M. S., Oslovsky V. E., Kurochkin N. N., Solyev P. N., Kozlovskaya L. I., Palyulin V. A., Karganova G. G., Mikhailov S. N., Osolodkin D. I. New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors // Bioorganic and Medicinal Chemistry Letters. 2017. Vol. 27. No. 5. pp. 1267-1273.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2017.01.040
UR - https://doi.org/10.1016/j.bmcl.2017.01.040
TI - New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Drenichev, M. S.
AU - Oslovsky, V. E.
AU - Kurochkin, Nikolay N
AU - Solyev, Pavel N.
AU - Kozlovskaya, Liubov I.
AU - Palyulin, V. A.
AU - Karganova, Galina G.
AU - Mikhailov, Sergey N.
AU - Osolodkin, Dmitry I.
PY - 2017
DA - 2017/03/01
PB - Elsevier
SP - 1267-1273
IS - 5
VL - 27
PMID - 28159412
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Orlov,
author = {M. S. Drenichev and V. E. Oslovsky and Nikolay N Kurochkin and Pavel N. Solyev and Liubov I. Kozlovskaya and V. A. Palyulin and Galina G. Karganova and Sergey N. Mikhailov and Dmitry I. Osolodkin},
title = {New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2017},
volume = {27},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.bmcl.2017.01.040},
number = {5},
pages = {1267--1273},
doi = {10.1016/j.bmcl.2017.01.040}
}
Cite this
MLA
Copy
Orlov, Alexey A., et al. “New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors.” Bioorganic and Medicinal Chemistry Letters, vol. 27, no. 5, Mar. 2017, pp. 1267-1273. https://doi.org/10.1016/j.bmcl.2017.01.040.