Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection
Theres Meili
2
,
Oleg A. Rakitin
3, 4
,
Ilia V Baranovsky
4
,
Lidia S. Konstantinova
3, 4
,
Antti Poso
4
,
Publication type: Journal Article
Publication date: 2019-07-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
31101470
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
We report the first biological evaluation the 1,2,3-thiaselenazole class of compound and utilising a concise synthetic approach of sulfur extrusion, selenium insertion of the 1,2,3-dithiazoles. We created a small diverse library of compounds to contrast the two ring systems. This approach has highlighted new structure activity relationship insights and lead to the development of sub-micro molar anti-viral compounds with reduced toxicity. The 1,2,3-thiaselenazole represents a new class of potential compounds for the treatment of FIV and HIV.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
|
|
|
Antibiotics
3 publications, 9.38%
|
|
|
Molecules
3 publications, 9.38%
|
|
|
Bioorganic and Medicinal Chemistry
2 publications, 6.25%
|
|
|
Drug Discovery Today
2 publications, 6.25%
|
|
|
European Journal of Medicinal Chemistry
2 publications, 6.25%
|
|
|
New Journal of Chemistry
2 publications, 6.25%
|
|
|
Current Medicinal Chemistry
1 publication, 3.13%
|
|
|
MolBank
1 publication, 3.13%
|
|
|
Bioorganic and Medicinal Chemistry Letters
1 publication, 3.13%
|
|
|
ChemistrySelect
1 publication, 3.13%
|
|
|
Journal of Structural Chemistry
1 publication, 3.13%
|
|
|
Advances in Heterocyclic Chemistry
1 publication, 3.13%
|
|
|
ACS Omega
1 publication, 3.13%
|
|
|
Expert Opinion on Drug Discovery
1 publication, 3.13%
|
|
|
Russian Journal of General Chemistry
1 publication, 3.13%
|
|
|
Журнал Общей Химии
1 publication, 3.13%
|
|
|
Russian Chemical Bulletin
1 publication, 3.13%
|
|
|
RSC Medicinal Chemistry
1 publication, 3.13%
|
|
|
Monatshefte fur Chemie
1 publication, 3.13%
|
|
|
Frontiers in Veterinary Science
1 publication, 3.13%
|
|
|
Chemistry - An Asian Journal
1 publication, 3.13%
|
|
|
1
2
3
|
Publishers
|
2
4
6
8
10
|
|
|
Elsevier
10 publications, 31.25%
|
|
|
MDPI
7 publications, 21.88%
|
|
|
Royal Society of Chemistry (RSC)
4 publications, 12.5%
|
|
|
Pleiades Publishing
3 publications, 9.38%
|
|
|
Wiley
2 publications, 6.25%
|
|
|
Springer Nature
2 publications, 6.25%
|
|
|
Bentham Science Publishers Ltd.
1 publication, 3.13%
|
|
|
American Chemical Society (ACS)
1 publication, 3.13%
|
|
|
Taylor & Francis
1 publication, 3.13%
|
|
|
Frontiers Media S.A.
1 publication, 3.13%
|
|
|
2
4
6
8
10
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
32
Total citations:
32
Citations from 2024:
7
(21%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Asquith C. R. M. et al. Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection // Bioorganic and Medicinal Chemistry Letters. 2019. Vol. 29. No. 14. pp. 1765-1768.
GOST all authors (up to 50)
Copy
Asquith C. R. M., Meili T., Rakitin O. A., Baranovsky I. V., Konstantinova L. S., Poso A., Hofmann-Lehmann R. Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection // Bioorganic and Medicinal Chemistry Letters. 2019. Vol. 29. No. 14. pp. 1765-1768.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2019.05.016
UR - https://linkinghub.elsevier.com/retrieve/pii/S0960894X19303026
TI - Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Asquith, Christopher R M
AU - Meili, Theres
AU - Rakitin, Oleg A.
AU - Baranovsky, Ilia V
AU - Konstantinova, Lidia S.
AU - Poso, Antti
AU - Hofmann-Lehmann, Regina
PY - 2019
DA - 2019/07/01
PB - Elsevier
SP - 1765-1768
IS - 14
VL - 29
PMID - 31101470
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Asquith,
author = {Christopher R M Asquith and Theres Meili and Oleg A. Rakitin and Ilia V Baranovsky and Lidia S. Konstantinova and Antti Poso and Regina Hofmann-Lehmann},
title = {Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2019},
volume = {29},
publisher = {Elsevier},
month = {jul},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0960894X19303026},
number = {14},
pages = {1765--1768},
doi = {10.1016/j.bmcl.2019.05.016}
}
Cite this
MLA
Copy
Asquith, Christopher R. M., et al. “Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection.” Bioorganic and Medicinal Chemistry Letters, vol. 29, no. 14, Jul. 2019, pp. 1765-1768. https://linkinghub.elsevier.com/retrieve/pii/S0960894X19303026.