A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities☆
Тип публикации: Journal Article
Дата публикации: 2010-09-01
scimago Q1
wos Q1
БС1
SJR: 1.151
CiteScore: 11.7
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
20591538
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Краткое описание
A series of 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one derivatives were synthesized and tested for their antimicrobial and antiviral activities. Mannich base derivatives were prepared through the reaction of substituted piperazine or piperidine derivatives on chlorokojic acid and formaline. The structures of the synthesized compounds were confirmed by IR, (1)H and (13)C NMR, ESI-MS, and elemental analysis. According to the activity studies, compounds 2-7 (MIC: 1-2 microg/mL) were found to be highly active against Bacillus subtilis and Staphylococcus aureus, while compounds 3, 5 and 6 showed significant activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii. Also, compounds 2-7 were more remarkably active against Candida albicans and Candida parapsilosis (MIC: 4-8 microg/mL). Additionally, compound 2 was the most active one against RNA virus PI-3.
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ГОСТ
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Aytemir M. D., Özçelik B. A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities☆ // European Journal of Medicinal Chemistry. 2010. Vol. 45. No. 9. pp. 4089-4095.
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Aytemir M. D., Özçelik B. A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities☆ // European Journal of Medicinal Chemistry. 2010. Vol. 45. No. 9. pp. 4089-4095.
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TY - JOUR
DO - 10.1016/j.ejmech.2010.05.069
UR - https://doi.org/10.1016/j.ejmech.2010.05.069
TI - A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities☆
T2 - European Journal of Medicinal Chemistry
AU - Aytemir, Mutlu Dilsiz
AU - Özçelik, Berrin
PY - 2010
DA - 2010/09/01
PB - Elsevier
SP - 4089-4095
IS - 9
VL - 45
PMID - 20591538
SN - 0223-5234
SN - 1768-3254
ER -
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@article{2010_Aytemir,
author = {Mutlu Dilsiz Aytemir and Berrin Özçelik},
title = {A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities☆},
journal = {European Journal of Medicinal Chemistry},
year = {2010},
volume = {45},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.ejmech.2010.05.069},
number = {9},
pages = {4089--4095},
doi = {10.1016/j.ejmech.2010.05.069}
}
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MLA
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Aytemir, Mutlu Dilsiz, and Berrin Özçelik. “A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities☆.” European Journal of Medicinal Chemistry, vol. 45, no. 9, Sep. 2010, pp. 4089-4095. https://doi.org/10.1016/j.ejmech.2010.05.069.