A comprehensive overview of β-carbolines and its derivatives as anticancer agents
Publication type: Journal Article
Publication date: 2021-11-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
34332400
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
β-Carboline alkaloids are a family of natural and synthetic products with structural diversity and outstanding antitumor activities. This review summarizes research developments of β-carboline and its derivatives as anticancer agents, which focused on both natural and synthetic monomers as well as dimers. In addition, the structure-activity relationship (SAR) analysis of β-carboline monomers and dimers are summarized and mechanism of action of β-carboline and its derivatives are also presented. A few possible research directions, suggestions and clues for future work on the development of novel β-carboline-based anticancer agents with improved expected activities and lesser toxicity are also provided.
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78
Total citations:
78
Citations from 2025:
29
(37.18%)
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GOST
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Luo B., Song X. A comprehensive overview of β-carbolines and its derivatives as anticancer agents // European Journal of Medicinal Chemistry. 2021. Vol. 224. p. 113688.
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Luo B., Song X. A comprehensive overview of β-carbolines and its derivatives as anticancer agents // European Journal of Medicinal Chemistry. 2021. Vol. 224. p. 113688.
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TY - JOUR
DO - 10.1016/j.ejmech.2021.113688
UR - https://doi.org/10.1016/j.ejmech.2021.113688
TI - A comprehensive overview of β-carbolines and its derivatives as anticancer agents
T2 - European Journal of Medicinal Chemistry
AU - Luo, Bo
AU - Song, Xinqiang
PY - 2021
DA - 2021/11/01
PB - Elsevier
SP - 113688
VL - 224
PMID - 34332400
SN - 0223-5234
SN - 1768-3254
ER -
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@article{2021_Luo,
author = {Bo Luo and Xinqiang Song},
title = {A comprehensive overview of β-carbolines and its derivatives as anticancer agents},
journal = {European Journal of Medicinal Chemistry},
year = {2021},
volume = {224},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.ejmech.2021.113688},
pages = {113688},
doi = {10.1016/j.ejmech.2021.113688}
}