Phytomedicine

, том 12 , издание 4 , страницы 299-304

Chemical composition and anticancer activity of leaf essential oil of Myrica gale L.

Тип публикации: Journal Article

Дата публикации: 2005-04-01

Elsevier

Phytomedicine

scimago Q1

wos Q1

БС1

SJR: 1.694

CiteScore: 11.6

Impact factor: 8.3

ISSN: 09447113, 1618095X

DOI: 10.1016/j.phymed.2003.12.004

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PubMed ID: 15898708

Drug Discovery

Pharmacology

Pharmaceutical Science

Molecular Medicine

Complementary and alternative medicine

Краткое описание

Myrica gale L. (Myricaceae), a native plant from Canada used in traditional medicine, was extracted by hydrodistillation and the oil was collected after 30 and 60 min. The chemical composition of these two extracts was determined using GC-MS analysis. We identified 53 components and myrcene (23.18-12.14%), limonene (11.20-6.75%), alpha-phellandrene (9.90-6.49%) and beta-caryophyllene (9.31-10.97%) were the major components in the 30- and 60-min fractions, respectively, whereas higher caryophyllene oxide content was detected in the 60-min fraction (9.94%) than in the 30-min fraction (3.47%). The anticancer activities of these extracts were assessed against human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line, DLD-1. The 60-min fraction showed higher anticancer activity against both tumor cell lines with an IC50 value of 88 +/- 1 microg/ml. The 30-min fraction had an IC50 value of 184 +/- 4 microg/ml for A-549 and 160 +/- 3 microg/ml for DLD-1. The higher cell growth inhibition induced by the 60-min fraction, as compared to the 30-min fraction, could be due to sesquiterpene enrichment.

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Sylvestre M. et al. Chemical composition and anticancer activity of leaf essential oil of Myrica gale L. // Phytomedicine. 2005. Vol. 12. No. 4. pp. 299-304.

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Sylvestre M., Legault J., Dufour D., Pichette A. Chemical composition and anticancer activity of leaf essential oil of Myrica gale L. // Phytomedicine. 2005. Vol. 12. No. 4. pp. 299-304.

RIS |

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TY - JOUR

DO - 10.1016/j.phymed.2003.12.004

UR - https://doi.org/10.1016/j.phymed.2003.12.004

TI - Chemical composition and anticancer activity of leaf essential oil of Myrica gale L.

T2 - Phytomedicine

AU - Sylvestre, M.

AU - Legault, Jean

AU - Dufour, D.

AU - Pichette, André

PY - 2005

DA - 2005/04/01

PB - Elsevier

SP - 299-304

IS - 4

VL - 12

PMID - 15898708

SN - 0944-7113

SN - 1618-095X

ER -

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@article{2005_Sylvestre,

author = {M. Sylvestre and Jean Legault and D. Dufour and André Pichette},

title = {Chemical composition and anticancer activity of leaf essential oil of Myrica gale L.},

journal = {Phytomedicine},

year = {2005},

volume = {12},

publisher = {Elsevier},

month = {apr},

url = {https://doi.org/10.1016/j.phymed.2003.12.004},

number = {4},

pages = {299--304},

doi = {10.1016/j.phymed.2003.12.004}

}

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MLA Скопировать

Sylvestre, M., et al. “Chemical composition and anticancer activity of leaf essential oil of Myrica gale L..” Phytomedicine, vol. 12, no. 4, Apr. 2005, pp. 299-304. https://doi.org/10.1016/j.phymed.2003.12.004.

Издатель

Elsevier

Журнал

Phytomedicine

scimago Q1

wos Q1

БС1

SJR

1.694

CiteScore

11.6

Impact factor

8.3

ISSN

09447113 (Print)

1618095X (Electronic)