volume 117 issue 8 pages 5784-5863

Heteroatom–Heteroatom Bond Formation in Natural Product Biosynthesis

Publication typeJournal Article
Publication date2017-04-04
scimago Q1
wos Q1
SJR16.455
CiteScore100.5
Impact factor55.8
ISSN00092665, 15206890
General Chemistry
Abstract
Natural products that contain functional groups with heteroatom-heteroatom linkages (X-X, where X = N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and diversity of these structural motifs has captured the interest of synthetic and biological chemists alike. Functional groups containing X-X bonds are found in all major classes of natural products and often impart significant biological activity. This review presents our current understanding of the biosynthetic logic and enzymatic chemistry involved in the construction of X-X bond containing functional groups within natural products. Elucidating and characterizing biosynthetic pathways that generate X-X bonds could both provide tools for biocatalysis and synthetic biology, as well as guide efforts to uncover new natural products containing these structural features.
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GOST |
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GOST Copy
Waldman A. J. et al. Heteroatom–Heteroatom Bond Formation in Natural Product Biosynthesis // Chemical Reviews. 2017. Vol. 117. No. 8. pp. 5784-5863.
GOST all authors (up to 50) Copy
Waldman A. J., Ng T. L., Wang P., Balskus E. P. Heteroatom–Heteroatom Bond Formation in Natural Product Biosynthesis // Chemical Reviews. 2017. Vol. 117. No. 8. pp. 5784-5863.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1021/acs.chemrev.6b00621
UR - https://doi.org/10.1021/acs.chemrev.6b00621
TI - Heteroatom–Heteroatom Bond Formation in Natural Product Biosynthesis
T2 - Chemical Reviews
AU - Waldman, Abraham J
AU - Ng, Tai L
AU - Wang, Peng
AU - Balskus, Emily P.
PY - 2017
DA - 2017/04/04
PB - American Chemical Society (ACS)
SP - 5784-5863
IS - 8
VL - 117
PMID - 28375000
SN - 0009-2665
SN - 1520-6890
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2017_Waldman,
author = {Abraham J Waldman and Tai L Ng and Peng Wang and Emily P. Balskus},
title = {Heteroatom–Heteroatom Bond Formation in Natural Product Biosynthesis},
journal = {Chemical Reviews},
year = {2017},
volume = {117},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/acs.chemrev.6b00621},
number = {8},
pages = {5784--5863},
doi = {10.1021/acs.chemrev.6b00621}
}
MLA
Cite this
MLA Copy
Waldman, Abraham J., et al. “Heteroatom–Heteroatom Bond Formation in Natural Product Biosynthesis.” Chemical Reviews, vol. 117, no. 8, Apr. 2017, pp. 5784-5863. https://doi.org/10.1021/acs.chemrev.6b00621.