ACS Infectious Diseases, volume 9, issue 6, pages 1206-1220
Multicationic Quaternary Ammonium Compounds: A Framework for Combating Bacterial Resistance
Seferyan Mary A
1
,
Saverina Evgeniya A.
1, 2
,
Frolov Nikita A.
1
,
Detusheva Elena V
1, 3
,
Kamanina Olga A.
2
,
Ostashevskaya Irina I
1, 4
,
Publication type: Journal Article
Publication date: 2023-05-10
Journal:
ACS Infectious Diseases
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.3
ISSN: 23738227
Infectious Diseases
Abstract
During previous stages of research, high biocidal activity toward microorganism archival strains has been used as the main indicator in the development of new antiseptic formulations. Although this factor remains one of the most important characteristics of biocide efficiency, the scale of antimicrobial resistance spread causes serious concern. Therefore, focus shifts toward the development of formulations with a stable effect even in the case of prolonged contact with pathogens. Here, we introduce an original isocyanuric acid alkylation method with the use of available alkyl dichlorides, which opened access to a wide panel of multi-QACs with alkyl chains of various lengths between the nitrogen atoms of triazine and pyridine cycles. We used a complex approach for the resulting series of 17 compounds, including their antibiofilm properties, bacterial tolerance development, and antimicrobial activity toward multiresistant pathogenic strains. As a result of these efforts, available compounds have shown higher levels of antibacterial activity against ESKAPE pathogens than widely used commercial QACs. Hit compounds possessed high activity toward clinical bacterial strains and have also demonstrated a long-term biocidal effect without significant development of microorganism tolerance. The overall results indicated a high level of antibacterial activity and the broad application prospects of multi-QACs based on isocyanuric acid against multiresistant bacterial strains.
Citations by journals
|
1
|
|
|
Molecules
|
Molecules
1 publication, 11.11%
|
|
Tetrahedron
|
Tetrahedron
1 publication, 11.11%
|
|
Mendeleev Communications
|
Mendeleev Communications
1 publication, 11.11%
|
|
Pharmaceutics
|
Pharmaceutics
1 publication, 11.11%
|
|
Chemistry of Heterocyclic Compounds
|
Chemistry of Heterocyclic Compounds
1 publication, 11.11%
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
1 publication, 11.11%
|
|
ACS Infectious Diseases
|
ACS Infectious Diseases
1 publication, 11.11%
|
|
Russian Journal of Inorganic Chemistry
|
Russian Journal of Inorganic Chemistry
1 publication, 11.11%
|
|
1
|
Citations by publishers
|
1
2
3
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 33.33%
|
|
Elsevier
|
Elsevier
2 publications, 22.22%
|
|
Springer Nature
|
Springer Nature
1 publication, 11.11%
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
1 publication, 11.11%
|
|
Pleiades Publishing
|
Pleiades Publishing
1 publication, 11.11%
|
|
1
2
3
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2023,2024],"ids":[0,0],"codes":[0,0],"imageUrls":["",""],"datasets":[{"label":"Citations number","data":[6,3],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":["66.67","33.33"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Molecules","Tetrahedron","Mendeleev Communications","Pharmaceutics","Chemistry of Heterocyclic Compounds","International Journal of Molecular Sciences","ACS Infectious Diseases","Russian Journal of Inorganic Chemistry"],"ids":[1770,3439,5294,4502,16828,14627,7781,426],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[11.11,11.11,11.11,11.11,11.11,11.11,11.11,11.11],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Elsevier","Springer Nature","American Chemical Society (ACS)","Pleiades Publishing"],"ids":[202,17,8,40,101],"codes":[0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp"],"datasets":[{"label":"","data":[3,2,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[33.33,22.22,11.11,11.11,11.11],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Seferyan M. A. et al. Multicationic Quaternary Ammonium Compounds: A Framework for Combating Bacterial Resistance // ACS Infectious Diseases. 2023. Vol. 9. No. 6. pp. 1206-1220.
GOST all authors (up to 50)
Copy
Seferyan M. A., Saverina E. A., Frolov N. A., Detusheva E. V., Kamanina O. A., Arlyapov V. A., Ostashevskaya I. I., Ananikov V. P., Vereshchagin A. N. Multicationic Quaternary Ammonium Compounds: A Framework for Combating Bacterial Resistance // ACS Infectious Diseases. 2023. Vol. 9. No. 6. pp. 1206-1220.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acsinfecdis.2c00546
UR - https://doi.org/10.1021%2Facsinfecdis.2c00546
TI - Multicationic Quaternary Ammonium Compounds: A Framework for Combating Bacterial Resistance
T2 - ACS Infectious Diseases
AU - Seferyan, Mary A
AU - Saverina, Evgeniya A.
AU - Frolov, Nikita A.
AU - Detusheva, Elena V
AU - Kamanina, Olga A.
AU - Arlyapov, Vyacheslav A.
AU - Ostashevskaya, Irina I
AU - Ananikov, Valentine P.
AU - Vereshchagin, Anatoly N.
PY - 2023
DA - 2023/05/10 00:00:00
PB - American Chemical Society (ACS)
SP - 1206-1220
IS - 6
VL - 9
SN - 2373-8227
ER -
Cite this
BibTex
Copy
@article{2023_Seferyan,
author = {Mary A Seferyan and Evgeniya A. Saverina and Nikita A. Frolov and Elena V Detusheva and Olga A. Kamanina and Vyacheslav A. Arlyapov and Irina I Ostashevskaya and Valentine P. Ananikov and Anatoly N. Vereshchagin},
title = {Multicationic Quaternary Ammonium Compounds: A Framework for Combating Bacterial Resistance},
journal = {ACS Infectious Diseases},
year = {2023},
volume = {9},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021%2Facsinfecdis.2c00546},
number = {6},
pages = {1206--1220},
doi = {10.1021/acsinfecdis.2c00546}
}
Cite this
MLA
Copy
Seferyan, Mary A., et al. “Multicationic Quaternary Ammonium Compounds: A Framework for Combating Bacterial Resistance.” ACS Infectious Diseases, vol. 9, no. 6, May. 2023, pp. 1206-1220. https://doi.org/10.1021%2Facsinfecdis.2c00546.