Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d -ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis
Claudia Trefzer
1
,
Monica Rengifo Gonzalez
1
,
Monica Rengifo-Gonzalez
1
,
Marlon J. Hinner
1
,
Patricia Schneider
1
,
Vadim Makarov
1
,
Stewart T. Cole
1
,
Publication type: Journal Article
Publication date: 2010-09-09
scimago Q1
wos Q1
SJR: 5.554
CiteScore: 22.5
Impact factor: 15.6
ISSN: 00027863, 15205126
PubMed ID:
20828197
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Abstract
Benzothiazinones (BTZs) form a new class of potent antimycobacterial agents. Although the target of BTZs has been identified as decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1), their detailed mechanism of action remains obscure. Here we demonstrate that BTZs are activated in the bacterium by reduction of an essential nitro group to a nitroso derivative, which then specifically reacts with a cysteine residue in the active site of DprE1.
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Total citations:
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Citations from 2024:
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(12%)
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GOST
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Trefzer C. et al. Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis // Journal of the American Chemical Society. 2010. Vol. 132. No. 39. pp. 13663-13665.
GOST all authors (up to 50)
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Trefzer C., Rengifo Gonzalez M., Rengifo-Gonzalez M., Hinner M. J., Schneider P., Makarov V., Cole S. T., Johnsson K. Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis // Journal of the American Chemical Society. 2010. Vol. 132. No. 39. pp. 13663-13665.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/ja106357w
UR - https://pubs.acs.org/doi/10.1021/ja106357w
TI - Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis
T2 - Journal of the American Chemical Society
AU - Trefzer, Claudia
AU - Rengifo Gonzalez, Monica
AU - Rengifo-Gonzalez, Monica
AU - Hinner, Marlon J.
AU - Schneider, Patricia
AU - Makarov, Vadim
AU - Cole, Stewart T.
AU - Johnsson, Kai
PY - 2010
DA - 2010/09/09
PB - American Chemical Society (ACS)
SP - 13663-13665
IS - 39
VL - 132
PMID - 20828197
SN - 0002-7863
SN - 1520-5126
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2010_Trefzer,
author = {Claudia Trefzer and Monica Rengifo Gonzalez and Monica Rengifo-Gonzalez and Marlon J. Hinner and Patricia Schneider and Vadim Makarov and Stewart T. Cole and Kai Johnsson},
title = {Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis},
journal = {Journal of the American Chemical Society},
year = {2010},
volume = {132},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://pubs.acs.org/doi/10.1021/ja106357w},
number = {39},
pages = {13663--13665},
doi = {10.1021/ja106357w}
}
Cite this
MLA
Copy
Trefzer, Claudia, et al. “Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis.” Journal of the American Chemical Society, vol. 132, no. 39, Sep. 2010, pp. 13663-13665. https://pubs.acs.org/doi/10.1021/ja106357w.
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