Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences

Laboratory of Biomedical Chemistry

Medical Chemistry Pharmacology Organic Chemistry

Head of Laboratory

Makarov, Vadim Albertovich

DSc in Chemistry

Publications

168

Citations

4 063

h-index

Authorization required.

Lab website

We specialize in the early development of low molecular weight drugs and the development of probe molecules for the study of biological processes

Organic synthesis
Column chromatography
Mass spectrometry
Interphase catalysis
X-ray diffraction analysis
Synthesis of metabolites
Synthesis at high pressure
Thin-layer chromatography
UV spectroscopy
Pharmacodynamics
Pharmacokinetics
Phenotypic screening
NMR spectroscopy

Vadim Makarov 🥼 🤝

Head of Laboratory

Anna Egorova

Researcher

Research directions

Research directions will appear here soon

A description of the research direction will appear here soon

Publications and patents

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

Science (Q1), 2009, Citations: 603

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

EMBO Molecular Medicine (Q1), 2014, Citations: 317

New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3

Antiviral Research (Q1), 2009, Citations: 45

Pyrazolopyrimidines: Potent Inhibitors Targeting the Capsid of Rhino- and Enteroviruses

ChemMedChem (Q1), 2015, Citations: 34

Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses

European Journal of Medicinal Chemistry (Q1), 2020, Citations: 32

N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a New Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor

Journal of Medicinal Chemistry (Q1), 2023, Citations: 6

By date By citations

Производные 2-ацетамидо-6-гидрокси-бензотиофена и их фармацевтически приемлемые соли, обладающие противовирусной активностью

Вадим Альбертович Макаров, Владимир Викторович Зарубаев

RU2756587C9, 2021

Пираноиндолы с противотуберкулезной активностью

Вадим Альбертович Макаров, Александр Юльевич Лепешкин, Наталья Сергеевна Монахова, Елена Геннадиевна Салина

RU2675240C1, 2018

Способ получения (±)n-[1-(4-фторфенил)-2-(1-этилпиперидин-4-ил)этил]-4-нитробензамида или его фармацевтически приемлемых солей и промежуточное соединение для его получения

Вадим Альбертович Макаров

RU2566818C2, 2015

Производные циклических 5-нитропиридин-2-ил-тиоалкенил-4-дитиокарбаматов, обладающие противогрибковой активностью, и их применение

Вадим Альбертович Макаров, Виктор Васильевич Суровцев

RU2487132C1, 2013

Pyrimidyl-di(diazaspiro-alkanes) with antiviral activity

Vadim Albertovich MAKAROV, Vladimir Georgievich Nesterenko, Roman Nikolaevich BOLGARIN, Elena Alexandrovna NOVOSELOVA

WO2017069661, 2017

2-homopiperazine-1-yl-4h-1,3-benzothiazine-4-one derivatives and process for the preparation of 2- (homo)piperazine 1,3-benzothiazine-4-one hydrochlorides

Cole Stewart, Makarov Vadim ALBERTOVICH

WO2016151011, 2016

4, 6-di (3,12-diaza-6, 9-diazoniadispiro [5.2.5.2] hexandecan-1-yl) -2-methyl-5-nitropyrimidine tetrachloride dihydrochloride hexahydrate for the treatment of herpetic infection and a topical pharmaceutical composition

Vadim Albertovich MAKAROV, Natalia Sergeevna MONAKHOVA, Olga Borisovna RYABOVA

WO2015167368, 2015

4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidin-derivate, deren herstellung und deren verwendung als antivirale wirkstoffe

Peter Wutzler, Michaela Schmidtke, Vadim Makarov

WO2013053942, 2013

2-piperazin-1-yl-4h-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections

Vadim Makarov, Stewart Cole

WO2012066518, 2012

Process for the preparation of 2-amino-substituted 1,3-benzothiazine-4-ones

Vadim A. Makarov

WO2011132070, 2011

Факторы вирулентности Mycobacterium tuberculosis как новая мишень для малых молекул с перспективой создания лекарств с оригинальным механизмом действия

2021 — 2023

| Макаров Вадим Альбертович

Partners

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

I.I. Mechnikov Scientific Research Institute of Vaccines and Serums

Serbsky National Medical Research Center for Psychiatry and Narcology

Lab address

Москва, Ленинский проспект 33, к 1

Authorization required.