volume 59 issue 9 pages 843-849

Isolation and Characterization of Yunnaneic Acids A−D, Four Novel Caffeic Acid Metabolites from Salvia yunnanensis

TAKASHI TANAKA 1
Akiko Nishimura 1
Isao Kouno 1
Gen-ichiro NONAKA 1
Tsuong-Jen YOUNG 1
1
 
School of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852, Japan, Saga Prefectural Institute for Pharmaceutical Research, Shuku-machi, Tosu, Saga 841, Japan, and Kunming Plant Research Institute, Yunnan, China
Publication typeJournal Article
Publication date1996-01-01
scimago Q1
wos Q1
SJR0.629
CiteScore6.5
Impact factor3.6
ISSN01633864, 15206025
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
In the course of chemical studies on medicinal plants having uremic toxin-decreasing effects, the novel caffeic acid metabolites yunnaneic acids A−D were isolated from the roots of Salvia yunnanensis. Yunnaneic acids C and D were found to be caffeic acid trimers having a bicyclo[2.2.2]octene skeleton, which is biogenetically formed by a Diels−Alder-type addition between rosmarinic acid and caffeic acid. Yunnaneic acid A has a dimeric structure composed of yunnaneic acids C and D, which are linked by formation of a spiroacetal ring. Yunnaneic acid B consists of two molecules of yunnaneic acid C. The structures of the yunnaneic acids were elucidated on the basis of spectroscopic evidence, and their absolute configurations were established by application of the circular dichroic exciton chirality method.
Found 
Found 

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GOST Copy
TANAKA T. et al. Isolation and Characterization of Yunnaneic Acids A−D, Four Novel Caffeic Acid Metabolites from Salvia yunnanensis // Journal of Natural Products. 1996. Vol. 59. No. 9. pp. 843-849.
GOST all authors (up to 50) Copy
TANAKA T., Nishimura A., Kouno I., NONAKA G., YOUNG T. Isolation and Characterization of Yunnaneic Acids A−D, Four Novel Caffeic Acid Metabolites from Salvia yunnanensis // Journal of Natural Products. 1996. Vol. 59. No. 9. pp. 843-849.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1021/np960425s
UR - https://doi.org/10.1021/np960425s
TI - Isolation and Characterization of Yunnaneic Acids A−D, Four Novel Caffeic Acid Metabolites from Salvia yunnanensis
T2 - Journal of Natural Products
AU - TANAKA, TAKASHI
AU - Nishimura, Akiko
AU - Kouno, Isao
AU - NONAKA, Gen-ichiro
AU - YOUNG, Tsuong-Jen
PY - 1996
DA - 1996/01/01
PB - American Chemical Society (ACS)
SP - 843-849
IS - 9
VL - 59
SN - 0163-3864
SN - 1520-6025
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{1996_TANAKA,
author = {TAKASHI TANAKA and Akiko Nishimura and Isao Kouno and Gen-ichiro NONAKA and Tsuong-Jen YOUNG},
title = {Isolation and Characterization of Yunnaneic Acids A−D, Four Novel Caffeic Acid Metabolites from Salvia yunnanensis},
journal = {Journal of Natural Products},
year = {1996},
volume = {59},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/np960425s},
number = {9},
pages = {843--849},
doi = {10.1021/np960425s}
}
MLA
Cite this
MLA Copy
TANAKA, TAKASHI, et al. “Isolation and Characterization of Yunnaneic Acids A−D, Four Novel Caffeic Acid Metabolites from Salvia yunnanensis.” Journal of Natural Products, vol. 59, no. 9, Jan. 1996, pp. 843-849. https://doi.org/10.1021/np960425s.