Ciprofloxacin-Photoswitch Conjugates: A Facile Strategy for Photopharmacology.
2
Molecular
Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, Nijenborgh 7, 9747 AG, Groningen, The Netherlands
|
Publication type: Journal Article
Publication date: 2015-12-03
scimago Q1
wos Q1
SJR: 1.035
CiteScore: 7.5
Impact factor: 3.9
ISSN: 10431802, 15204812
PubMed ID:
26574623
Organic Chemistry
Pharmacology
Pharmaceutical Science
Biotechnology
Bioengineering
Biomedical Engineering
Abstract
Photopharmacology aims to locally treat diseases and study biological processes with photoresponsive drugs. Herein, easy access to photoswitchable drugs is crucial, which is supported by simple and robust drug modifications. We investigated the possibility of creating drugs that can undergo remote activation and deactivation with light, by conjugating molecular photoswitches to the exterior of an existing drug in a single chemical step. This facile strategy allows the convenient introduction of various photochromic systems into a drug molecule, rendering it photoresponsive. To demonstrate the feasibility of this approach, two photoswitch-modified ciprofloxacin antibiotics were synthesized. Remarkably, for one of them a 50-fold increase in activity compared to the original ciprofloxacin was observed. Their antimicrobial activity could be spatiotemporally controlled with light, which was exemplified by bacterial patterning studies.
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98
Total citations:
98
Citations from 2025:
8
(8.16%)
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GOST
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Velema W. A. et al. Ciprofloxacin-Photoswitch Conjugates: A Facile Strategy for Photopharmacology. // Bioconjugate Chemistry. 2015. Vol. 26. No. 12. pp. 2592-2597.
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Velema W. A., Hansen M. J., Lerch M. M., Driessen A., Szymanski W., Feringa B. L. Ciprofloxacin-Photoswitch Conjugates: A Facile Strategy for Photopharmacology. // Bioconjugate Chemistry. 2015. Vol. 26. No. 12. pp. 2592-2597.
Cite this
RIS
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TY - JOUR
DO - 10.1021/acs.bioconjchem.5b00591
UR - https://doi.org/10.1021/acs.bioconjchem.5b00591
TI - Ciprofloxacin-Photoswitch Conjugates: A Facile Strategy for Photopharmacology.
T2 - Bioconjugate Chemistry
AU - Velema, Willem A
AU - Hansen, Mickel J
AU - Lerch, Michael M
AU - Driessen, A.
AU - Szymanski, Wiktor
AU - Feringa, Ben L.
PY - 2015
DA - 2015/12/03
PB - American Chemical Society (ACS)
SP - 2592-2597
IS - 12
VL - 26
PMID - 26574623
SN - 1043-1802
SN - 1520-4812
ER -
Cite this
BibTex (up to 50 authors)
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@article{2015_Velema,
author = {Willem A Velema and Mickel J Hansen and Michael M Lerch and A. Driessen and Wiktor Szymanski and Ben L. Feringa},
title = {Ciprofloxacin-Photoswitch Conjugates: A Facile Strategy for Photopharmacology.},
journal = {Bioconjugate Chemistry},
year = {2015},
volume = {26},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/acs.bioconjchem.5b00591},
number = {12},
pages = {2592--2597},
doi = {10.1021/acs.bioconjchem.5b00591}
}
Cite this
MLA
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Velema, Willem A., et al. “Ciprofloxacin-Photoswitch Conjugates: A Facile Strategy for Photopharmacology..” Bioconjugate Chemistry, vol. 26, no. 12, Dec. 2015, pp. 2592-2597. https://doi.org/10.1021/acs.bioconjchem.5b00591.