Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area
Daniil V. Spector
1, 2
,
Alexander S. Erofeev
1, 2
,
Petr V. Gorelkin
2
,
Alexander N. Vaneev
1, 2
,
Roman A. Akasov
3, 4
,
Nikolay V Ulyanovskiy
5
,
Vita N. Nikitina
1
,
Alevtina S. Semkina
6, 7
,
Kseniya Yu. Vlasova
1, 6
,
Mikhail Soldatov
8
,
Nikolay V. Zyk
1
,
Dmitry A. Sakharov
10
,
Alexander G. Majouga
1, 2, 10
,
Olga O. Krasnovskaya
1, 2
1
2
5
6
9
Тип публикации: Journal Article
Дата публикации: 2022-09-01
scimago Q1
wos Q1
БС1
SJR: 0.958
CiteScore: 7.4
Impact factor: 4.7
ISSN: 00201669, 1520510X
PubMed ID:
36047922
Inorganic Chemistry
Physical and Theoretical Chemistry
Краткое описание
We report herein a Pt(IV) prodrug with metronidazole in axial positions Pt-Mnz. The nitroaromatic axial ligand was conjugated with a cisplatin scaffold to irreversibly reduce under hypoxic conditions, thereby retaining the Pt(IV) prodrug in the area of hypoxia. X-ray near-edge adsorption spectroscopy (XANES) on dried drug-preincubated tumor cell samples revealed a gradual release of cisplatin from the Pt-Mnz prodrug instead of rapid intracellular degradation. The ability of the prodrug to penetrate into three-dimensional (3D) spheroid cellular cultures was evaluated by a novel electrochemical assay via a platinum-coated carbon nanoelectrode, capable of single-cell measurements. Using a unique technique of electrochemical measurements in single tumor spheroids, we were able to both detect the real-time response of the axial ligand to hypoxia and establish the depth of penetration of the drug into the tumor model.
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Spector D. V. et al. Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area // Inorganic Chemistry. 2022. Vol. 61. No. 37. pp. 14705-14717.
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Spector D. V., Erofeev A. S., Gorelkin P. V., Vaneev A. N., Akasov R. A., Ulyanovskiy N. V., Nikitina V. N., Semkina A. S., Vlasova K. Y., Soldatov M., Trigub A. L., Skvortsov D. A., Finko A. V., Zyk N. V., Sakharov D. A., Majouga A. G., Beloglazkina E. K., Krasnovskaya O. O. Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area // Inorganic Chemistry. 2022. Vol. 61. No. 37. pp. 14705-14717.
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TY - JOUR
DO - 10.1021/acs.inorgchem.2c02062
UR - https://pubs.acs.org/doi/10.1021/acs.inorgchem.2c02062
TI - Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area
T2 - Inorganic Chemistry
AU - Spector, Daniil V.
AU - Erofeev, Alexander S.
AU - Gorelkin, Petr V.
AU - Vaneev, Alexander N.
AU - Akasov, Roman A.
AU - Ulyanovskiy, Nikolay V
AU - Nikitina, Vita N.
AU - Semkina, Alevtina S.
AU - Vlasova, Kseniya Yu.
AU - Soldatov, Mikhail
AU - Trigub, Alexander L
AU - Skvortsov, Dmitry A.
AU - Finko, Alexander V
AU - Zyk, Nikolay V.
AU - Sakharov, Dmitry A.
AU - Majouga, Alexander G.
AU - Beloglazkina, Elena K.
AU - Krasnovskaya, Olga O.
PY - 2022
DA - 2022/09/01
PB - American Chemical Society (ACS)
SP - 14705-14717
IS - 37
VL - 61
PMID - 36047922
SN - 0020-1669
SN - 1520-510X
ER -
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@article{2022_Spector,
author = {Daniil V. Spector and Alexander S. Erofeev and Petr V. Gorelkin and Alexander N. Vaneev and Roman A. Akasov and Nikolay V Ulyanovskiy and Vita N. Nikitina and Alevtina S. Semkina and Kseniya Yu. Vlasova and Mikhail Soldatov and Alexander L Trigub and Dmitry A. Skvortsov and Alexander V Finko and Nikolay V. Zyk and Dmitry A. Sakharov and Alexander G. Majouga and Elena K. Beloglazkina and Olga O. Krasnovskaya},
title = {Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area},
journal = {Inorganic Chemistry},
year = {2022},
volume = {61},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://pubs.acs.org/doi/10.1021/acs.inorgchem.2c02062},
number = {37},
pages = {14705--14717},
doi = {10.1021/acs.inorgchem.2c02062}
}
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Spector, Daniil V., et al. “Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area.” Inorganic Chemistry, vol. 61, no. 37, Sep. 2022, pp. 14705-14717. https://pubs.acs.org/doi/10.1021/acs.inorgchem.2c02062.