Journal of Agricultural and Food Chemistry

, том 66 , издание 40 , страницы 10438-10446

Could Fecal Phenylacetic and Phenylpropionic Acids Be Used as Indicators of Health Status?

Тип публикации: Journal Article

Дата публикации: 2018-09-18

American Chemical Society (ACS)

Journal of Agricultural and Food Chemistry

SCImago Q1

Tоп 10% SCImago

WOS Q1

БС1

SJR: 1.206

CiteScore: 9.5

Impact factor: 6.7

ISSN: 00218561, 15205118

DOI: 10.1021/acs.jafc.8b04102

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PubMed ID: 30227707

General Chemistry

General Agricultural and Biological Sciences

Краткое описание

Although most of the health effects attributed to polyphenols may be linked to their phenolic-derived metabolites, the role of the intestinal derived-phenolics in human health is still far from being well understood. We determined the profile of fecal phenolic-derived metabolites, microbiota, biomarkers of oxidative stress and inflammation, and daily intake of bioactive compounds in 71 elderly volunteers. Phenylacetic and phenylpropionic acids were the main phenolic metabolites present in feces. From them, phenylacetic acid was related with a more pro-oxidant and immune stimulated status, and both were negatively associated with fecal propionate, whereas phenylpropionic acid was directly related with the fecal concentration of acetate. Moreover, phenylacetic acid was negatively associated with the Bacteroides group and Clostridium cluster XIVa and positively with Lactobacillus. These results provide a rationale to explore the potential of fecal microbial phenolic-derived metabolites as possible biomarkers of health status in future studies focused on the elderly population.

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Gutiérrez Díaz I. et al. Could Fecal Phenylacetic and Phenylpropionic Acids Be Used as Indicators of Health Status? // Journal of Agricultural and Food Chemistry. 2018. Vol. 66. No. 40. pp. 10438-10446.

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Gutiérrez Díaz I., Fernández Navarro T., Salazar N., Bartolomé B., Moreno-Arribas M. V., López P., Suárez A., De Los Reyes-Gavilan C. G., Gueimonde M., González S. Could Fecal Phenylacetic and Phenylpropionic Acids Be Used as Indicators of Health Status? // Journal of Agricultural and Food Chemistry. 2018. Vol. 66. No. 40. pp. 10438-10446.

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