A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine
Kevin A Scott
1, 2
,
M Haziq Qureshi
1
,
Philip B Cox
3
,
Christopher M Marshall
1
,
Bailey C Bellaire
1
,
Michael Wilcox
1
,
Bradey A R Stuart
1
,
3
Drug Discovery Science and Technology, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States
|
Publication type: Journal Article
Publication date: 2020-10-30
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
33125236
Drug Discovery
Molecular Medicine
Abstract
The FDA Green Book is a list of all drug products that have been approved by the FDA for use in veterinary medicine. The Green Book, as published, lacks structural information corresponding to approved drugs. To address this gap, we have compiled the structural data for all FDA Green Book drugs approved through the end of 2019. Herein we discuss the relevance of this data set to human drugs in the context of structural classes and physicochemical properties. Analysis reveals that physicochemical properties are highly optimized and consistent with a high probability of favorable drug metabolism and pharmacokinetic properties, including good oral bioavailability for most compounds. We provide a detailed analysis of this data set organized on the basis of structure and function. Slightly over half (51%) of vet drugs are also approved in human medicine. Combination drugs are biologics are also discussed.
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Total citations:
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Citations from 2024:
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(36.58%)
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GOST
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Scott K. A. et al. A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine // Journal of Medicinal Chemistry. 2020. Vol. 63. No. 24. pp. 15449-15482.
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Scott K. A., Qureshi M. H., Cox P. B., Marshall C. M., Bellaire B. C., Wilcox M., Stuart B. A. R., Njardarson J. T. A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine // Journal of Medicinal Chemistry. 2020. Vol. 63. No. 24. pp. 15449-15482.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.jmedchem.0c01502
UR - https://doi.org/10.1021/acs.jmedchem.0c01502
TI - A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine
T2 - Journal of Medicinal Chemistry
AU - Scott, Kevin A
AU - Qureshi, M Haziq
AU - Cox, Philip B
AU - Marshall, Christopher M
AU - Bellaire, Bailey C
AU - Wilcox, Michael
AU - Stuart, Bradey A R
AU - Njardarson, J. T.
PY - 2020
DA - 2020/10/30
PB - American Chemical Society (ACS)
SP - 15449-15482
IS - 24
VL - 63
PMID - 33125236
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Scott,
author = {Kevin A Scott and M Haziq Qureshi and Philip B Cox and Christopher M Marshall and Bailey C Bellaire and Michael Wilcox and Bradey A R Stuart and J. T. Njardarson},
title = {A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine},
journal = {Journal of Medicinal Chemistry},
year = {2020},
volume = {63},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/acs.jmedchem.0c01502},
number = {24},
pages = {15449--15482},
doi = {10.1021/acs.jmedchem.0c01502}
}
Cite this
MLA
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Scott, Kevin A., et al. “A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine.” Journal of Medicinal Chemistry, vol. 63, no. 24, Oct. 2020, pp. 15449-15482. https://doi.org/10.1021/acs.jmedchem.0c01502.
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