Journal of Medicinal Chemistry

, том 63 , издание 24 , страницы 15449-15482

A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine

Kevin A Scott ^{1, 2}

M Haziq Qureshi ¹

Philip B Cox ³

Christopher M Marshall ¹

Bailey C Bellaire ¹

Michael Wilcox ¹

Bradey A R Stuart ¹

J. T. Njardarson ¹

Скрыть аффилиации авторов Показать аффилиации авторов: 3 аффилиации

Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States |

Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721, United States |

Drug Discovery Science and Technology, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States |

Тип публикации: Journal Article

Дата публикации: 2020-10-30

American Chemical Society (ACS)

Journal of Medicinal Chemistry

scimago Q1

wos Q1

БС1

SJR: 1.801

CiteScore: 11.5

Impact factor: 6.8

ISSN: 00222623, 15204804

DOI: 10.1021/acs.jmedchem.0c01502

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PubMed ID: 33125236

Drug Discovery

Molecular Medicine

Краткое описание

The FDA Green Book is a list of all drug products that have been approved by the FDA for use in veterinary medicine. The Green Book, as published, lacks structural information corresponding to approved drugs. To address this gap, we have compiled the structural data for all FDA Green Book drugs approved through the end of 2019. Herein we discuss the relevance of this data set to human drugs in the context of structural classes and physicochemical properties. Analysis reveals that physicochemical properties are highly optimized and consistent with a high probability of favorable drug metabolism and pharmacokinetic properties, including good oral bioavailability for most compounds. We provide a detailed analysis of this data set organized on the basis of structure and function. Slightly over half (51%) of vet drugs are also approved in human medicine. Combination drugs are biologics are also discussed.

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Scott K. A. et al. A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine // Journal of Medicinal Chemistry. 2020. Vol. 63. No. 24. pp. 15449-15482.

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Scott K. A., Qureshi M. H., Cox P. B., Marshall C. M., Bellaire B. C., Wilcox M., Stuart B. A. R., Njardarson J. T. A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine // Journal of Medicinal Chemistry. 2020. Vol. 63. No. 24. pp. 15449-15482.

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TY - JOUR

DO - 10.1021/acs.jmedchem.0c01502

UR - https://doi.org/10.1021/acs.jmedchem.0c01502

TI - A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine

T2 - Journal of Medicinal Chemistry

AU - Scott, Kevin A

AU - Qureshi, M Haziq

AU - Cox, Philip B

AU - Marshall, Christopher M

AU - Bellaire, Bailey C

AU - Wilcox, Michael

AU - Stuart, Bradey A R

AU - Njardarson, J. T.

PY - 2020

DA - 2020/10/30

PB - American Chemical Society (ACS)

SP - 15449-15482

IS - 24

VL - 63

PMID - 33125236

SN - 0022-2623

SN - 1520-4804

ER -

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@article{2020_Scott,

author = {Kevin A Scott and M Haziq Qureshi and Philip B Cox and Christopher M Marshall and Bailey C Bellaire and Michael Wilcox and Bradey A R Stuart and J. T. Njardarson},

title = {A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine},

journal = {Journal of Medicinal Chemistry},

year = {2020},

volume = {63},

publisher = {American Chemical Society (ACS)},

month = {oct},

url = {https://doi.org/10.1021/acs.jmedchem.0c01502},

number = {24},

pages = {15449--15482},

doi = {10.1021/acs.jmedchem.0c01502}

}

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Scott, Kevin A., et al. “A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine.” Journal of Medicinal Chemistry, vol. 63, no. 24, Oct. 2020, pp. 15449-15482. https://doi.org/10.1021/acs.jmedchem.0c01502.