Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2)
Publication type: Journal Article
Publication date: 2017-04-17
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
28388065
Drug Discovery
Molecular Medicine
Abstract
Carbapenem-resistant Enterobacteriaceae are resistant to most β-lactam antibiotics due to the production of the Klebsiella pneumoniae carbapenemase (KPC-2) class A β-lactamase. Here, we present the first product complex crystal structures of KPC-2 with β-lactam antibiotics containing hydrolyzed cefotaxime and faropenem. They provide experimental insights into substrate recognition by KPC-2 and its unique cephalosporinase/carbapenemase activity. These structures also represent the first product complexes for a wild-type serine β-lactamase, elucidating the product release mechanism of these enzymes in general.
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53
Total citations:
53
Citations from 2024:
11
(20%)
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GOST
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Pemberton O. A., Zhang X., Chen Yu. Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2) // Journal of Medicinal Chemistry. 2017. Vol. 60. No. 8. pp. 3525-3530.
GOST all authors (up to 50)
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Pemberton O. A., Zhang X., Chen Yu. Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2) // Journal of Medicinal Chemistry. 2017. Vol. 60. No. 8. pp. 3525-3530.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.jmedchem.7b00158
UR - https://doi.org/10.1021/acs.jmedchem.7b00158
TI - Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2)
T2 - Journal of Medicinal Chemistry
AU - Pemberton, Orville A
AU - Zhang, Xiujun
AU - Chen, Yu
PY - 2017
DA - 2017/04/17
PB - American Chemical Society (ACS)
SP - 3525-3530
IS - 8
VL - 60
PMID - 28388065
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Pemberton,
author = {Orville A Pemberton and Xiujun Zhang and Yu Chen},
title = {Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2)},
journal = {Journal of Medicinal Chemistry},
year = {2017},
volume = {60},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/acs.jmedchem.7b00158},
number = {8},
pages = {3525--3530},
doi = {10.1021/acs.jmedchem.7b00158}
}
Cite this
MLA
Copy
Pemberton, Orville A., et al. “Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).” Journal of Medicinal Chemistry, vol. 60, no. 8, Apr. 2017, pp. 3525-3530. https://doi.org/10.1021/acs.jmedchem.7b00158.