Langmuir, volume 34, issue 11, pages 3449-3458

PMIDA-Modified Fe3O4 Magnetic Nanoparticles: Synthesis and Application for Liver MRI

Demin Alexander V. ¹

Pershina Alexandra G. ^{2, 3}

Minin A.S. ⁴

Mekhaev Alexander V ¹

Ivanov Vladimir V. ²

Lezhava Sofiya P ²

Zakharova Alexandra A ³

Byzov Iliya V ⁴

Uimin M.A. ⁴

Krasnov Victor P. ¹

Ogorodova Ludmila M ²

Hide authors affiliations Show authors affiliations: 4 affiliations

Postovsky Institute of Organic Synthesis of RAS (Ural Branch), 22 S. Kovalevskoy Street, 620990 Yekaterinburg, Russia |

Siberian State Medical University, 2 Moskovsky Trakt, 634050 Tomsk, Russia |

National Research Tomsk Polytechnic University, 30 Lenina Avenue, Tomsk 634050, Russia |

⁴

Miheev Institute of Metal Physics of RAS (Ural Branch), 18 S. Kovalevskoy Street, 620990 Yekaterinburg, Russia |

Publication type: Journal Article

Publication date: 2018-02-24

American Chemical Society (ACS)

Journal: Langmuir

Quartile SCImago

Quartile WOS

Impact factor: 3.9

ISSN: 07437463, 15205827

DOI: 10.1021/acs.langmuir.7b04023

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Spectroscopy

Electrochemistry

Condensed Matter Physics

General Materials Science

Surfaces and Interfaces

Abstract

The surface modification of Fe3O4-based magnetic nanoparticles (MNPs) with N-(phosphonomethyl)iminodiacetic acid (PMIDA) was studied, and the possibility of their use as magnetic resonance imaging contrast agents was shown. The effect of the added PMIDA amount, the reaction temperature and time on the degree of immobilization of this reagent on MNPs, and the hydrodynamic characteristics of their aqueous colloidal solutions have been systematically investigated for the first time. It has been shown that the optimum condition for the modification of MNPs is the reaction at 40 °C with an equimolar amount of PMIDA for 3.5 h. The modified MNPs were characterized by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric, and CHN elemental analyses. The dependence of the hydrodynamic characteristics of the MNP colloidal solutions on the concentration and pH of the medium was studied by the dynamic light scattering method. On the basis of the obtained data, we can assume that the PMIDA molecules are fixed on the surface of the MNPs as a monomolecular layer. The modified MNPs had good colloidal stability and high magnetic properties. The calculated relaxivities r2 and r1 were 341 and 102 mmol-1 s-1, respectively. The possibility of using colloidal solutions of PMIDA-modified MNPs as a T2 contrast agent for liver studies in vivo (at a dose of 0.6 mg kg-1) was demonstrated for the first time.

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Journal of Magnetism and Magnetic Materials	Journal of Magnetism and Magnetic Materials, 1, 2.38% Journal of Magnetism and Magnetic Materials 1 publication, 2.38%
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Colloids and Surfaces A: Physicochemical and Engineering Aspects	Colloids and Surfaces A: Physicochemical and Engineering Aspects, 1, 2.38% Colloids and Surfaces A: Physicochemical and Engineering Aspects 1 publication, 2.38%
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Langmuir	Langmuir, 1, 2.38% Langmuir 1 publication, 2.38%
Chemistry of Materials	Chemistry of Materials, 1, 2.38% Chemistry of Materials 1 publication, 2.38%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 1, 2.38% Journal of Materials Chemistry B 1 publication, 2.38%
Nanotechnology Reviews	Nanotechnology Reviews, 1, 2.38% Nanotechnology Reviews 1 publication, 2.38%
Bulletin of Experimental Biology and Medicine	Bulletin of Experimental Biology and Medicine, 1, 2.38% Bulletin of Experimental Biology and Medicine 1 publication, 2.38%
ACS Symposium Series	ACS Symposium Series, 1, 2.38% ACS Symposium Series 1 publication, 2.38%
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Elsevier	Elsevier, 12, 28.57% Elsevier 12 publications, 28.57%
Springer Nature	Springer Nature, 8, 19.05% Springer Nature 8 publications, 19.05%
American Chemical Society (ACS)	American Chemical Society (ACS), 5, 11.9% American Chemical Society (ACS) 5 publications, 11.9%
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Pleiades Publishing	Pleiades Publishing, 1, 2.38% Pleiades Publishing 1 publication, 2.38%
Taylor & Francis	Taylor & Francis, 1, 2.38% Taylor & Francis 1 publication, 2.38%
Future Medicine	Future Medicine, 1, 2.38% Future Medicine 1 publication, 2.38%
Higher Education Press	Higher Education Press, 1, 2.38% Higher Education Press 1 publication, 2.38%
IOP Publishing	IOP Publishing, 1, 2.38% IOP Publishing 1 publication, 2.38%
Wiley	Wiley, 1, 2.38% Wiley 1 publication, 2.38%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 2.38% Royal Society of Chemistry (RSC) 1 publication, 2.38%
Walter de Gruyter	Walter de Gruyter, 1, 2.38% Walter de Gruyter 1 publication, 2.38%
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Demin A. V. et al. PMIDA-Modified Fe3O4 Magnetic Nanoparticles: Synthesis and Application for Liver MRI // Langmuir. 2018. Vol. 34. No. 11. pp. 3449-3458.

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Demin A. V., Pershina A. G., Minin A., Mekhaev A. V., Ivanov V. V., Lezhava S. P., Zakharova A. A., Byzov I. V., Uimin M., Krasnov V. P., Ogorodova L. M. PMIDA-Modified Fe3O4 Magnetic Nanoparticles: Synthesis and Application for Liver MRI // Langmuir. 2018. Vol. 34. No. 11. pp. 3449-3458.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acs.langmuir.7b04023

UR - https://doi.org/10.1021%2Facs.langmuir.7b04023

TI - PMIDA-Modified Fe3O4 Magnetic Nanoparticles: Synthesis and Application for Liver MRI

T2 - Langmuir

AU - Mekhaev, Alexander V

AU - Zakharova, Alexandra A

AU - Byzov, Iliya V

AU - Demin, Alexander V.

AU - Minin, A.S.

AU - Pershina, Alexandra G.

AU - Ivanov, Vladimir V.

AU - Lezhava, Sofiya P

AU - Uimin, M.A.

AU - Krasnov, Victor P.

AU - Ogorodova, Ludmila M

PY - 2018

DA - 2018/02/24 00:00:00

PB - American Chemical Society (ACS)

SP - 3449-3458

IS - 11

VL - 34

SN - 0743-7463

SN - 1520-5827

ER -

BibTex |

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BibTex Copy

@article{2018_Demin,

author = {Alexander V Mekhaev and Alexandra A Zakharova and Iliya V Byzov and Alexander V. Demin and A.S. Minin and Alexandra G. Pershina and Vladimir V. Ivanov and Sofiya P Lezhava and M.A. Uimin and Victor P. Krasnov and Ludmila M Ogorodova},

title = {PMIDA-Modified Fe3O4 Magnetic Nanoparticles: Synthesis and Application for Liver MRI},

journal = {Langmuir},

year = {2018},

volume = {34},

publisher = {American Chemical Society (ACS)},

month = {feb},

url = {https://doi.org/10.1021%2Facs.langmuir.7b04023},

number = {11},

pages = {3449--3458},

doi = {10.1021/acs.langmuir.7b04023}

}

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MLA Copy

Demin, Alexander V., et al. “PMIDA-Modified Fe3O4 Magnetic Nanoparticles: Synthesis and Application for Liver MRI.” Langmuir, vol. 34, no. 11, Feb. 2018, pp. 3449-3458. https://doi.org/10.1021%2Facs.langmuir.7b04023.

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Publisher

American Chemical Society (ACS)

Journal

Langmuir

Quartile SCImago

Quartile WOS

Impact factor

3.9

ISSN

07437463 (Print)
15205827 (Electronic)

Labs

Laboratory of Applied Magnetism

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