ACS applied materials & interfaces, volume 13, issue 31, pages 36800-36815
Smart Design of a pH-Responsive System Based on pHLIP-Modified Magnetite Nanoparticles for Tumor MRI
Pershina Alexandra G.
2, 3
,
Minin A.S.
4
,
Brikunova Olga Ya
3
,
Murzakaev Aidar M
5, 6
,
Perekucha Natalya A
2
,
Romashchenko Alexander V
7
,
Shevelev Oleg B
7
,
Uimin M.A.
4
,
Byzov Iliya V
4
,
Malkeyeva Dina
7
,
Kiseleva Elena
7
,
Efimova Lina V
2
,
Vtorushin Sergey V.
2, 8
,
Ogorodova Ludmila M
2
,
5
6
Publication type: Journal Article
Publication date: 2021-07-29
Journal:
ACS applied materials & interfaces
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 9.5
ISSN: 19448244, 19448252
General Materials Science
Abstract
Magnetic Fe3O4 nanoparticles (MNPs) are often used to design agents enhancing contrast in magnetic resonance imaging (MRI) that can be considered as one of the efficient methods for cancer diagnostics. At present, increasing the specificity of the MRI contrast agent accumulation in tumor tissues remains an open question and attracts the attention of a wide range of researchers. One of the modern methods for enhancing the efficiency of contrast agents is the use of molecules for tumor acidic microenvironment targeting, for example, pH-low insertion peptide (pHLIP). We designed novel organosilicon MNPs covered with poly(ethylene glycol) (PEG) and covalently modified by pHLIP. To study the specific features of the binding of pHLIP-modified MNPs to cells, we also obtained nanoconjugates with Cy5 fluorescent dye embedded in the SiO2 shell. The nanoconjugates obtained were characterized by transmission electron microscopy (TEM), attenuated total reflection (ATR), diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), dynamic light scattering (DLS), UV and fluorescence spectrometry, thermogravimetric analysis (TGA), CHN elemental analyses, and vibrating sample magnetometry. Low cytotoxicity and high specificity of cellular uptake of pHLIP-modified MNPs at pH 6.4 versus 7.4 (up to 23-fold) were demonstrated in vitro. The dynamics of the nanoconjugate accumulation in the 4T1 breast cancer orthotopically grown in BALB/c mice and MDA-MB231 xenografts was evaluated in MRI experiments. Biodistribution and biocompatibility studies of the obtained nanoconjugate showed no pathological change in organs and in the blood biochemical parameters of mice after MNP administration. A high accumulation rate of pHLIP-modified MNPs in tumor compared with PEGylated MNPs after their intravenous administration was demonstrated. Thus, we propose a promising approach to design an MRI agent with the tumor acidic microenvironment targeting ability.
Citations by journals
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International Journal of Molecular Sciences
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International Journal of Biological Macromolecules
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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Citations by publishers
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7
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3 publications, 12.5%
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American Chemical Society (ACS)
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3 publications, 12.5%
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Wiley
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Wiley
2 publications, 8.33%
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KeAi Communications Co.
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KeAi Communications Co.
1 publication, 4.17%
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Springer Nature
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Springer Nature
1 publication, 4.17%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 4.17%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Demin A. V. et al. Smart Design of a pH-Responsive System Based on pHLIP-Modified Magnetite Nanoparticles for Tumor MRI // ACS applied materials & interfaces. 2021. Vol. 13. No. 31. pp. 36800-36815.
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Demin A. V., Pershina A. G., Minin A., Brikunova O. Ya., Murzakaev A. M., Perekucha N. A., Romashchenko A. V., Shevelev O. B., Uimin M., Byzov I. V., Malkeyeva D., Kiseleva E., Efimova L. V., Vtorushin S. V., Ogorodova L. M., Krasnov V. P. Smart Design of a pH-Responsive System Based on pHLIP-Modified Magnetite Nanoparticles for Tumor MRI // ACS applied materials & interfaces. 2021. Vol. 13. No. 31. pp. 36800-36815.
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TY - JOUR
DO - 10.1021/acsami.1c07748
UR - https://doi.org/10.1021%2Facsami.1c07748
TI - Smart Design of a pH-Responsive System Based on pHLIP-Modified Magnetite Nanoparticles for Tumor MRI
T2 - ACS applied materials & interfaces
AU - Brikunova, Olga Ya
AU - Perekucha, Natalya A
AU - Byzov, Iliya V
AU - Efimova, Lina V
AU - Demin, Alexander V.
AU - Minin, A.S.
AU - Pershina, Alexandra G.
AU - Murzakaev, Aidar M
AU - Romashchenko, Alexander V
AU - Shevelev, Oleg B
AU - Uimin, M.A.
AU - Malkeyeva, Dina
AU - Kiseleva, Elena
AU - Vtorushin, Sergey V.
AU - Ogorodova, Ludmila M
AU - Krasnov, Victor P.
PY - 2021
DA - 2021/07/29 00:00:00
PB - American Chemical Society (ACS)
SP - 36800-36815
IS - 31
VL - 13
SN - 1944-8244
SN - 1944-8252
ER -
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@article{2021_Demin,
author = {Olga Ya Brikunova and Natalya A Perekucha and Iliya V Byzov and Lina V Efimova and Alexander V. Demin and A.S. Minin and Alexandra G. Pershina and Aidar M Murzakaev and Alexander V Romashchenko and Oleg B Shevelev and M.A. Uimin and Dina Malkeyeva and Elena Kiseleva and Sergey V. Vtorushin and Ludmila M Ogorodova and Victor P. Krasnov},
title = {Smart Design of a pH-Responsive System Based on pHLIP-Modified Magnetite Nanoparticles for Tumor MRI},
journal = {ACS applied materials & interfaces},
year = {2021},
volume = {13},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021%2Facsami.1c07748},
number = {31},
pages = {36800--36815},
doi = {10.1021/acsami.1c07748}
}
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Demin, Alexander V., et al. “Smart Design of a pH-Responsive System Based on pHLIP-Modified Magnetite Nanoparticles for Tumor MRI.” ACS applied materials & interfaces, vol. 13, no. 31, Jul. 2021, pp. 36800-36815. https://doi.org/10.1021%2Facsami.1c07748.