Journal of Medicinal Chemistry

, volume 57 , issue 14 , pages 6252-6258

Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity

Alexander G. Majouga ^{1, 2}

Maria Zvereva ^{1, 3}

Maria I. Zvereva ^{4, 5}

Maria Rubtsova ^{1, 3}

Maria P Rubtsova ^{4, 5}

Dmitry Skvortsov ¹

Dmitry A. Skvortsov ⁴

Andrei V. Mironov ^{1, 4}

Dulat M Azhibek ^{1, 6}

Olga O. Krasnovskaya ¹

Vasily M Gerasimov ^{1, 4}

Anna V Udina ^{1, 4}

Nikolay I Vorozhtsov ^{1, 4}

Elena K. Beloglazkina ¹

Leonid Agron ^{1, 4}

Larisa V Mikhina ^{7, 8}

Alla V Tretyakova ^{7, 8}

Nikolay V. Zyk ^{1, 4}

Nikolay S. Zefirov ^{1, 4}

A.A. Kabanov ^{1, 9}

Alexander V Kabanov ^{4, 10}

Olga A. Dontsova ^{1, 3, 4, 5}

Hide authors affiliations Show authors affiliations: 10 affiliations

Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russian Federation |

National University of Science and Technology MISiS, Leninsky Ave, 4, 119049 Moscow, Russian Federation |

Belozersky Institute, Lomonosov Moscow State University, Leninskie Gory, 1/40, 119992 Moscow, Russian Federation |

⁴

Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russian Federation |

⁵

Belozersky Institute, Lomonosov Moscow State University, Leninskie Gory, 1/40, 119992 Moscow, Russian Federation |

⁶

Skolkovo Institute of Science and Technology, Ul. Novaya, d. 100, Skolkovo 143025, Russian Federation |

⁷

Federal State-Financed Institution “Research Center for Toxicology and Hygienic Regulation of Biopreparations”, Federal Medico-Biological Agency, 102A, Lenin Str., Serpukhov, Moscow Region142253, Russian Federation |

⁸

⁹

Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, Eshelman School of PharmacyUniversity of North Carolina at Chapel Hill, , Genetic Medicine Building, room 1094, Campus Box 7362, Chapel Hill, North Carolina 27599-7362, United States |

¹⁰

Publication type: Journal Article

Publication date: 2014-07-08

American Chemical Society (ACS)

Journal of Medicinal Chemistry

scimago Q1

wos Q1

SJR: 1.801

CiteScore: 11.5

Impact factor: 6.8

ISSN: 00222623, 15204804

DOI: 10.1021/jm500154f

Copy DOI

PubMed ID: 24950478

Drug Discovery

Molecular Medicine

Abstract

We have synthesized and characterized a panel of new binuclear mixed valence Cu(I,II) complexes containing substituted 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones with unusual structure. These complexes are shown to be cytotoxic for various cell lines. We have found that these compounds did not intercalate DNA, inhibited number of polymerases (telomerase predominantly), accumulated in the cell nucleus, and caused DNA degradation. Preliminary studies revealed that lead compound inhibited human breast adenocarcinoma growth in mice model.

Found

25 citations

Beloglazkina Elena

DSc in Chemistry, professor

296 publications, 3 214 citations, 11 reviews

h-index: 29

Lomonosov Moscow State University

14 citations

Krasnovskaya Olga

52 publications, 862 citations, 10 reviews

h-index: 17

Lomonosov Moscow State University

13 citations

Skvortsov Dmitry

🥼

PhD in Chemistry

128 publications, 1 834 citations, 1 review

h-index: 26

Lomonosov Moscow State University

6 citations

Finko Alexander

PhD in Chemistry, associate professor

49 publications, 225 citations, 2 reviews

h-index: 8

A.V. Topchiev Institute of Petrochemical Synthesis RAS

Lomonosov Moscow State University

3 citations

Borisov Roman

🤝

PhD in Chemistry

184 publications, 1 708 citations, 19 reviews

h-index: 20

A.V. Topchiev Institute of Petrochemical Synthesis RAS

Peoples' Friendship University of Russia

Research interests

Mass Spectrometry

3 citations

Timoshenko Roman

28 publications, 241 citations

h-index: 10

2 citations

Akasov Roman

🥼 🤝

PhD in Biological/biomedical sciences

73 publications, 1 270 citations, 26 reviews

h-index: 22

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Kurchatov Complex of Crystallography and Photonics of NRC «Kurchatov Institute»

Sechenov First Moscow State Medical University

2 citations

Soldatov Alexander

600 publications, 11 116 citations

h-index: 52

Southern Federal University

2 citations

Vadekhina Veronika

10 publications, 17 citations

h-index: 2

Serbsky National Medical Research Center for Psychiatry and Narcology

National University of Science & Technology (MISiS)

Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

Pirogov Russian National Research Medical University

2 citations

Grigorkevich Oksana

13 publications, 11 citations

h-index: 2

2 citations

Salikhov Sergey

PhD in Physics and Mathematics, associate professor

26 publications, 333 citations

h-index: 8

National University of Science & Technology (MISiS)

Research interests

Materials Science

Symmetry

X-ray diffraction analysis

1 citation

Komlev Aleksei

🥼 🤝

PhD in Physics and Mathematics

46 publications, 398 citations

h-index: 11

Lomonosov Moscow State University

National Research Centre "Kurchatov Institute"

Research interests

Magnetism

1 citation

Aksenov Aleksandr

🥼 🤝

DSc in Chemistry, professor

243 publications, 2 163 citations, 15 reviews

h-index: 24

North Caucasus Federal University

Research interests

Medicinal Chemistry

Organic Chemistry

1 citation

Dzhemileva Lilya

🥼

DSc in Health sciences, associate professor

127 publications, 1 273 citations, 70 reviews

h-index: 21

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Institute of Physiologically Active Compounds of the Russian Academy of Science

Mendeleev University of Chemical Technology of Russia

Endocrinology Research Centre

1 citation

Dubrovin Evgeniy

DSc in Physics and Mathematics

54 publications, 651 citations, 5 reviews

h-index: 14

Lomonosov Moscow State University

Sirius University of Science and Technology

1 citation

Chmelyuk Nelly

25 publications, 201 citations

h-index: 8

National University of Science & Technology (MISiS)

Pirogov Russian National Research Medical University

1 citation

Zakharova Lucia

DSc in Chemistry, professor

394 publications, 6 131 citations

h-index: 36

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

1 citation

Osyanin Vitaly

DSc in Chemistry, professor

131 publications, 1 133 citations, 3 reviews

h-index: 16

Samara State Technical University

Research interests

Organic Chemistry

Top-30

Journals

	2 4 6 8 10 12 14
Polyhedron	Polyhedron, 13, 16.25% Polyhedron 13 publications, 16.25%
Journal of Inorganic Biochemistry	Journal of Inorganic Biochemistry, 8, 10% Journal of Inorganic Biochemistry 8 publications, 10%
Inorganica Chimica Acta	Inorganica Chimica Acta, 5, 6.25% Inorganica Chimica Acta 5 publications, 6.25%
Arabian Journal of Chemistry	Arabian Journal of Chemistry, 3, 3.75% Arabian Journal of Chemistry 3 publications, 3.75%
Dalton Transactions	Dalton Transactions, 3, 3.75% Dalton Transactions 3 publications, 3.75%
Russian Chemical Bulletin	Russian Chemical Bulletin, 3, 3.75% Russian Chemical Bulletin 3 publications, 3.75%
Mendeleev Communications	Mendeleev Communications, 3, 3.75% Mendeleev Communications 3 publications, 3.75%
Applied Organometallic Chemistry	Applied Organometallic Chemistry, 3, 3.75% Applied Organometallic Chemistry 3 publications, 3.75%
RSC Advances	RSC Advances, 2, 2.5% RSC Advances 2 publications, 2.5%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 2, 2.5% European Journal of Medicinal Chemistry 2 publications, 2.5%
ACS Omega	ACS Omega, 2, 2.5% ACS Omega 2 publications, 2.5%
Russian Journal of General Chemistry	Russian Journal of General Chemistry, 2, 2.5% Russian Journal of General Chemistry 2 publications, 2.5%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 1.25% International Journal of Molecular Sciences 1 publication, 1.25%
Phosphorus, Sulfur and Silicon and the Related Elements	Phosphorus, Sulfur and Silicon and the Related Elements, 1, 1.25% Phosphorus, Sulfur and Silicon and the Related Elements 1 publication, 1.25%
Inorganic Chemistry Communication	Inorganic Chemistry Communication, 1, 1.25% Inorganic Chemistry Communication 1 publication, 1.25%
Bioorganic and Medicinal Chemistry	Bioorganic and Medicinal Chemistry, 1, 1.25% Bioorganic and Medicinal Chemistry 1 publication, 1.25%
Russian Journal of Organic Chemistry	Russian Journal of Organic Chemistry, 1, 1.25% Russian Journal of Organic Chemistry 1 publication, 1.25%
Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 1, 1.25% Journal of Medicinal Chemistry 1 publication, 1.25%
Inorganic Chemistry Frontiers	Inorganic Chemistry Frontiers, 1, 1.25% Inorganic Chemistry Frontiers 1 publication, 1.25%
Nanotechnologies in Russia	Nanotechnologies in Russia, 1, 1.25% Nanotechnologies in Russia 1 publication, 1.25%
ChemistrySelect	ChemistrySelect, 1, 1.25% ChemistrySelect 1 publication, 1.25%
Journal of Biological Inorganic Chemistry	Journal of Biological Inorganic Chemistry, 1, 1.25% Journal of Biological Inorganic Chemistry 1 publication, 1.25%
Journal of Photochemistry and Photobiology B: Biology	Journal of Photochemistry and Photobiology B: Biology, 1, 1.25% Journal of Photochemistry and Photobiology B: Biology 1 publication, 1.25%
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 1, 1.25% Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 1 publication, 1.25%
Journal of Molecular Structure	Journal of Molecular Structure, 1, 1.25% Journal of Molecular Structure 1 publication, 1.25%
Drug Discovery Today	Drug Discovery Today, 1, 1.25% Drug Discovery Today 1 publication, 1.25%
Chemico-Biological Interactions	Chemico-Biological Interactions, 1, 1.25% Chemico-Biological Interactions 1 publication, 1.25%
Dyes and Pigments	Dyes and Pigments, 1, 1.25% Dyes and Pigments 1 publication, 1.25%
Luminescence	Luminescence, 1, 1.25% Luminescence 1 publication, 1.25%
	2 4 6 8 10 12 14

Publishers

	5 10 15 20 25 30 35 40
Elsevier	Elsevier, 37, 46.25% Elsevier 37 publications, 46.25%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 8, 10% Royal Society of Chemistry (RSC) 8 publications, 10%
Wiley	Wiley, 8, 10% Wiley 8 publications, 10%
Springer Nature	Springer Nature, 6, 7.5% Springer Nature 6 publications, 7.5%
Pleiades Publishing	Pleiades Publishing, 6, 7.5% Pleiades Publishing 6 publications, 7.5%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 5% American Chemical Society (ACS) 4 publications, 5%
OOO Zhurnal "Mendeleevskie Soobshcheniya"	OOO Zhurnal "Mendeleevskie Soobshcheniya", 3, 3.75% OOO Zhurnal "Mendeleevskie Soobshcheniya" 3 publications, 3.75%
MDPI	MDPI, 2, 2.5% MDPI 2 publications, 2.5%
Taylor & Francis	Taylor & Francis, 2, 2.5% Taylor & Francis 2 publications, 2.5%
Scientific Scholar	Scientific Scholar, 1, 1.25% Scientific Scholar 1 publication, 1.25%
King Saud University	King Saud University, 1, 1.25% King Saud University 1 publication, 1.25%
Georg Thieme Verlag KG	Georg Thieme Verlag KG, 1, 1.25% Georg Thieme Verlag KG 1 publication, 1.25%
	5 10 15 20 25 30 35 40

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Majouga A. G. et al. Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity // Journal of Medicinal Chemistry. 2014. Vol. 57. No. 14. pp. 6252-6258.

GOST all authors (up to 50) Copy

Majouga A. G., Zvereva M., Zvereva M. I., Rubtsova M., Rubtsova M. P., Skvortsov D., Skvortsov D. A., Mironov A. V., Azhibek D. M., Krasnovskaya O. O., Gerasimov V. M., Udina A. V., Vorozhtsov N. I., Beloglazkina E. K., Agron L., Mikhina L. V., Tretyakova A. V., Zyk N. V., Zefirov N. S., Kabanov A., Kabanov A. V., Dontsova O. A. Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity // Journal of Medicinal Chemistry. 2014. Vol. 57. No. 14. pp. 6252-6258.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1021/jm500154f

UR - https://pubs.acs.org/doi/10.1021/jm500154f

TI - Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity

T2 - Journal of Medicinal Chemistry

AU - Majouga, Alexander G.

AU - Zvereva, Maria

AU - Zvereva, Maria I.

AU - Rubtsova, Maria

AU - Rubtsova, Maria P

AU - Skvortsov, Dmitry

AU - Skvortsov, Dmitry A.

AU - Mironov, Andrei V.

AU - Azhibek, Dulat M

AU - Krasnovskaya, Olga O.

AU - Gerasimov, Vasily M

AU - Udina, Anna V

AU - Vorozhtsov, Nikolay I

AU - Beloglazkina, Elena K.

AU - Agron, Leonid

AU - Mikhina, Larisa V

AU - Tretyakova, Alla V

AU - Zyk, Nikolay V.

AU - Zefirov, Nikolay S.

AU - Kabanov, A.A.

AU - Kabanov, Alexander V

AU - Dontsova, Olga A.

PY - 2014

DA - 2014/07/08

PB - American Chemical Society (ACS)

SP - 6252-6258

IS - 14

VL - 57

PMID - 24950478

SN - 0022-2623

SN - 1520-4804

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2014_Majouga,

author = {Alexander G. Majouga and Maria Zvereva and Maria I. Zvereva and Maria Rubtsova and Maria P Rubtsova and Dmitry Skvortsov and Dmitry A. Skvortsov and Andrei V. Mironov and Dulat M Azhibek and Olga O. Krasnovskaya and Vasily M Gerasimov and Anna V Udina and Nikolay I Vorozhtsov and Elena K. Beloglazkina and Leonid Agron and Larisa V Mikhina and Alla V Tretyakova and Nikolay V. Zyk and Nikolay S. Zefirov and A.A. Kabanov and Alexander V Kabanov and Olga A. Dontsova},

title = {Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity},

journal = {Journal of Medicinal Chemistry},

year = {2014},

volume = {57},

publisher = {American Chemical Society (ACS)},

month = {jul},

url = {https://pubs.acs.org/doi/10.1021/jm500154f},

number = {14},

pages = {6252--6258},

doi = {10.1021/jm500154f}

}

MLA

Cite this

MLA Copy

Majouga, Alexander G., et al. “Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity.” Journal of Medicinal Chemistry, vol. 57, no. 14, Jul. 2014, pp. 6252-6258. https://pubs.acs.org/doi/10.1021/jm500154f.

Publisher

American Chemical Society (ACS)

Journal

Journal of Medicinal Chemistry

scimago Q1

wos Q1

SJR

1.801

CiteScore

11.5

Impact factor

6.8

ISSN

00222623 (Print)

15204804 (Electronic)

Labs

Profiles