Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity
Тип публикации: Journal Article
Дата публикации: 2014-07-08
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
24950478
Drug Discovery
Molecular Medicine
Краткое описание
We have synthesized and characterized a panel of new binuclear mixed valence Cu(I,II) complexes containing substituted 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones with unusual structure. These complexes are shown to be cytotoxic for various cell lines. We have found that these compounds did not intercalate DNA, inhibited number of polymerases (telomerase predominantly), accumulated in the cell nucleus, and caused DNA degradation. Preliminary studies revealed that lead compound inhibited human breast adenocarcinoma growth in mice model.
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Majouga A. G. et al. Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity // Journal of Medicinal Chemistry. 2014. Vol. 57. No. 14. pp. 6252-6258.
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Majouga A. G., Zvereva M., Zvereva M. I., Rubtsova M., Rubtsova M. P., Skvortsov D., Skvortsov D. A., Mironov A. V., Azhibek D. M., Krasnovskaya O. O., Gerasimov V. M., Udina A. V., Vorozhtsov N. I., Beloglazkina E. K., Agron L., Mikhina L. V., Tretyakova A. V., Zyk N. V., Zefirov N. S., Kabanov A., Kabanov A. V., Dontsova O. A. Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity // Journal of Medicinal Chemistry. 2014. Vol. 57. No. 14. pp. 6252-6258.
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TY - JOUR
DO - 10.1021/jm500154f
UR - https://pubs.acs.org/doi/10.1021/jm500154f
TI - Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity
T2 - Journal of Medicinal Chemistry
AU - Majouga, Alexander G.
AU - Zvereva, Maria
AU - Zvereva, Maria I.
AU - Rubtsova, Maria
AU - Rubtsova, Maria P
AU - Skvortsov, Dmitry
AU - Skvortsov, Dmitry A.
AU - Mironov, Andrei V.
AU - Azhibek, Dulat M
AU - Krasnovskaya, Olga O.
AU - Gerasimov, Vasily M
AU - Udina, Anna V
AU - Vorozhtsov, Nikolay I
AU - Beloglazkina, Elena K.
AU - Agron, Leonid
AU - Mikhina, Larisa V
AU - Tretyakova, Alla V
AU - Zyk, Nikolay V.
AU - Zefirov, Nikolay S.
AU - Kabanov, A.A.
AU - Kabanov, Alexander V
AU - Dontsova, Olga A.
PY - 2014
DA - 2014/07/08
PB - American Chemical Society (ACS)
SP - 6252-6258
IS - 14
VL - 57
PMID - 24950478
SN - 0022-2623
SN - 1520-4804
ER -
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@article{2014_Majouga,
author = {Alexander G. Majouga and Maria Zvereva and Maria I. Zvereva and Maria Rubtsova and Maria P Rubtsova and Dmitry Skvortsov and Dmitry A. Skvortsov and Andrei V. Mironov and Dulat M Azhibek and Olga O. Krasnovskaya and Vasily M Gerasimov and Anna V Udina and Nikolay I Vorozhtsov and Elena K. Beloglazkina and Leonid Agron and Larisa V Mikhina and Alla V Tretyakova and Nikolay V. Zyk and Nikolay S. Zefirov and A.A. Kabanov and Alexander V Kabanov and Olga A. Dontsova},
title = {Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity},
journal = {Journal of Medicinal Chemistry},
year = {2014},
volume = {57},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://pubs.acs.org/doi/10.1021/jm500154f},
number = {14},
pages = {6252--6258},
doi = {10.1021/jm500154f}
}
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MLA
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Majouga, Alexander G., et al. “Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity.” Journal of Medicinal Chemistry, vol. 57, no. 14, Jul. 2014, pp. 6252-6258. https://pubs.acs.org/doi/10.1021/jm500154f.