Journal of Medicinal Chemistry, volume 57, issue 14, pages 6252-6258
Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity
Majouga Alexander G.
1, 2
,
Zvereva Maria
2, 3
,
Rubtsova Maria
2, 3
,
Skvortsov Dmitry
2
,
Mironov Andrei V.
2
,
Azhibek Dulat M
2, 4
,
Gerasimov Vasily M
2
,
Udina Anna V
2
,
Vorozhtsov Nikolay I
2
,
Agron Leonid
2
,
Mikhina Larisa V
5
,
Tretyakova Alla V
5
,
Zyk Nikolay V.
2
,
Zefirov Nikolay S.
2
,
Kabanov A.A.
2, 6
,
Dontsova Olga A.
2, 3
5
Federal
State-Financed Institution āResearch Center for Toxicology
and Hygienic Regulation of Biopreparationsā, Federal Medico-Biological Agency, 102A, Lenin Str., Serpukhov, Moscow Region142253, Russian Federation
|
6
Center
for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics,
Eshelman School of PharmacyUniversity of North Carolina at Chapel Hill, , Genetic Medicine Building, room 1094, Campus Box 7362, Chapel Hill, North Carolina 27599-7362, United States
|
Publication type: Journal Article
Publication date: 2014-07-08
Journal:
Journal of Medicinal Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.3
ISSN: 00222623, 15204804
Drug Discovery
Molecular Medicine
Abstract
We have synthesized and characterized a panel of new binuclear mixed valence Cu(I,II) complexes containing substituted 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones with unusual structure. These complexes are shown to be cytotoxic for various cell lines. We have found that these compounds did not intercalate DNA, inhibited number of polymerases (telomerase predominantly), accumulated in the cell nucleus, and caused DNA degradation. Preliminary studies revealed that lead compound inhibited human breast adenocarcinoma growth in mice model.
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- Statistics recalculated weekly.
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Majouga A. G. et al. Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity // Journal of Medicinal Chemistry. 2014. Vol. 57. No. 14. pp. 6252-6258.
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Majouga A. G., Zvereva M., Rubtsova M., Skvortsov D., Mironov A. V., Azhibek D. M., Krasnovskaya O. O., Gerasimov V. M., Udina A. V., Vorozhtsov N. I., Beloglazkina E. K., Agron L., Mikhina L. V., Tretyakova A. V., Zyk N. V., Zefirov N. S., Kabanov A., Dontsova O. A. Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity // Journal of Medicinal Chemistry. 2014. Vol. 57. No. 14. pp. 6252-6258.
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TY - JOUR
DO - 10.1021/jm500154f
UR - https://doi.org/10.1021%2Fjm500154f
TI - Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity
T2 - Journal of Medicinal Chemistry
AU - Mironov, Andrei V.
AU - Gerasimov, Vasily M
AU - Udina, Anna V
AU - Vorozhtsov, Nikolay I
AU - Agron, Leonid
AU - Mikhina, Larisa V
AU - Tretyakova, Alla V
AU - Zyk, Nikolay V.
AU - Zefirov, Nikolay S.
AU - Dontsova, Olga A.
AU - Majouga, Alexander G.
AU - Zvereva, Maria
AU - Rubtsova, Maria
AU - Skvortsov, Dmitry
AU - Azhibek, Dulat M
AU - Krasnovskaya, Olga O.
AU - Beloglazkina, Elena K.
AU - Kabanov, A.A.
PY - 2014
DA - 2014/07/08 00:00:00
PB - American Chemical Society (ACS)
SP - 6252-6258
IS - 14
VL - 57
SN - 0022-2623
SN - 1520-4804
ER -
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@article{2014_Majouga,
author = {Andrei V. Mironov and Vasily M Gerasimov and Anna V Udina and Nikolay I Vorozhtsov and Leonid Agron and Larisa V Mikhina and Alla V Tretyakova and Nikolay V. Zyk and Nikolay S. Zefirov and Olga A. Dontsova and Alexander G. Majouga and Maria Zvereva and Maria Rubtsova and Dmitry Skvortsov and Dulat M Azhibek and Olga O. Krasnovskaya and Elena K. Beloglazkina and A.A. Kabanov},
title = {Mixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity},
journal = {Journal of Medicinal Chemistry},
year = {2014},
volume = {57},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021%2Fjm500154f},
number = {14},
pages = {6252--6258},
doi = {10.1021/jm500154f}
}
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MLA
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Majouga, Alexander G., et al. āMixed valence copper(I,II) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity.ā Journal of Medicinal Chemistry, vol. 57, no. 14, Jul. 2014, pp. 6252-6258. https://doi.org/10.1021%2Fjm500154f.