Tunable Encapsulation of Proteins within Charged Microgels
Publication type: Journal Article
Publication date: 2011-09-28
scimago Q1
wos Q1
SJR: 1.352
CiteScore: 9.0
Impact factor: 5.2
ISSN: 00249297, 15205835
PubMed ID:
22058574
Materials Chemistry
Organic Chemistry
Inorganic Chemistry
Polymers and Plastics
Abstract
The binding of cytochrome c to pH and thermoresponsive colloidal hydrogels was investigated using multiangle light scattering, measuring loading through changes in particle molar mass and root mean square radius. Loosely cross-linked microgels [composed of a random copolymer of N-isopropylacrylamide (NIPAm) and acrylic acid (AAc)] demonstrated a high loading capacity for protein. Encapsulation was dependent on both the charge characteristics of the network and the salinity of the medium. Under favorable binding conditions (neutral pH, low ionic strength), microgels containing the highest studied charge density (30 mol% AAc) were capable of encapsulating greater than 9.7 × 10(5) cytochrome c molecules per particle. Binding resulted in the formation of a polymer-protein complex and condensation of the polymer. Anionic microgels demonstrated a change in density ~20-fold in the presence of oppositely charged proteins. These studies of cytochrome c encapsulation represent a significant step towards direct measurement of encapsulation efficiency in complex media as we pursue responsive nanogels and microgels for the delivery of macromolecular therapeutic agents.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
6
7
8
9
|
|
|
Biomacromolecules
9 publications, 10.59%
|
|
|
Soft Matter
9 publications, 10.59%
|
|
|
Langmuir
7 publications, 8.24%
|
|
|
Journal of the American Chemical Society
4 publications, 4.71%
|
|
|
Polymers
3 publications, 3.53%
|
|
|
Polymer
3 publications, 3.53%
|
|
|
Journal of Materials Chemistry B
3 publications, 3.53%
|
|
|
Polymer Journal
2 publications, 2.35%
|
|
|
Journal of Colloid and Interface Science
2 publications, 2.35%
|
|
|
Analytica Chimica Acta
2 publications, 2.35%
|
|
|
Journal of Polymer Science
2 publications, 2.35%
|
|
|
Angewandte Chemie
2 publications, 2.35%
|
|
|
Angewandte Chemie - International Edition
2 publications, 2.35%
|
|
|
Macromolecular Bioscience
2 publications, 2.35%
|
|
|
Macromolecules
2 publications, 2.35%
|
|
|
ACS Applied Bio Materials
2 publications, 2.35%
|
|
|
Journal of Chemical Physics
1 publication, 1.18%
|
|
|
Therapeutic Delivery
1 publication, 1.18%
|
|
|
Gels
1 publication, 1.18%
|
|
|
Acta Polymerica Sinica
1 publication, 1.18%
|
|
|
Colloid and Polymer Science
1 publication, 1.18%
|
|
|
Nature Protocols
1 publication, 1.18%
|
|
|
ACS applied materials & interfaces
1 publication, 1.18%
|
|
|
Journal of Physics Condensed Matter
1 publication, 1.18%
|
|
|
Biomedical Materials (Bristol)
1 publication, 1.18%
|
|
|
Food Research International
1 publication, 1.18%
|
|
|
Polymer International
1 publication, 1.18%
|
|
|
Advanced Functional Materials
1 publication, 1.18%
|
|
|
Advanced Materials Interfaces
1 publication, 1.18%
|
|
|
1
2
3
4
5
6
7
8
9
|
Publishers
|
5
10
15
20
25
30
35
|
|
|
American Chemical Society (ACS)
31 publications, 36.47%
|
|
|
Royal Society of Chemistry (RSC)
16 publications, 18.82%
|
|
|
Wiley
12 publications, 14.12%
|
|
|
Elsevier
10 publications, 11.76%
|
|
|
MDPI
4 publications, 4.71%
|
|
|
Springer Nature
4 publications, 4.71%
|
|
|
IOP Publishing
2 publications, 2.35%
|
|
|
AIP Publishing
1 publication, 1.18%
|
|
|
Taylor & Francis
1 publication, 1.18%
|
|
|
China Science Publishing & Media
1 publication, 1.18%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 1.18%
|
|
|
Georg Thieme Verlag KG
1 publication, 1.18%
|
|
|
5
10
15
20
25
30
35
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
85
Total citations:
85
Citations from 2025:
3
(3.53%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Smith M. H., Lyon L. A. Tunable Encapsulation of Proteins within Charged Microgels // Macromolecules. 2011. Vol. 44. No. 20. pp. 8154-8160.
GOST all authors (up to 50)
Copy
Smith M. H., Lyon L. A. Tunable Encapsulation of Proteins within Charged Microgels // Macromolecules. 2011. Vol. 44. No. 20. pp. 8154-8160.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/ma201365p
UR - https://doi.org/10.1021/ma201365p
TI - Tunable Encapsulation of Proteins within Charged Microgels
T2 - Macromolecules
AU - Smith, Michael H.
AU - Lyon, L. A.
PY - 2011
DA - 2011/09/28
PB - American Chemical Society (ACS)
SP - 8154-8160
IS - 20
VL - 44
PMID - 22058574
SN - 0024-9297
SN - 1520-5835
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2011_Smith,
author = {Michael H. Smith and L. A. Lyon},
title = {Tunable Encapsulation of Proteins within Charged Microgels},
journal = {Macromolecules},
year = {2011},
volume = {44},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/ma201365p},
number = {20},
pages = {8154--8160},
doi = {10.1021/ma201365p}
}
Cite this
MLA
Copy
Smith, Michael H., and L. A. Lyon. “Tunable Encapsulation of Proteins within Charged Microgels.” Macromolecules, vol. 44, no. 20, Sep. 2011, pp. 8154-8160. https://doi.org/10.1021/ma201365p.