Method for Analysis of Nanoparticle Hemolytic Properties in Vitro
Publication type: Journal Article
Publication date: 2008-07-08
scimago Q1
wos Q1
SJR: 2.967
CiteScore: 14.9
Impact factor: 9.1
ISSN: 15306984, 15306992
PubMed ID:
18605701
General Chemistry
Condensed Matter Physics
General Materials Science
Mechanical Engineering
Bioengineering
Abstract
Hemolysis (destruction of red blood cells) in vivo can lead to anemia, jaundice, and other pathological conditions; therefore the hemolytic potential of all intravenously administered pharmaceuticals must be evaluated. Nanotechnology-derived devices and drug carriers are emerging as alternatives to conventional small-molecule drugs, and in vitro evaluation of their biocompatibility with blood components is a necessary part of early preclinical development. The small size and unique physicochemical properties of nanoparticles may cause their interactions with erythrocytes to differ from those observed for conventional pharmaceuticals and may also cause interference with standardized in vitro tests. Separating true hemolytic responses from the false-positive or false-negative results caused by particle interference is important for correct interpretation of these tests. Here we describe validation of an in vitro assay for the analysis of nanoparticle hemolytic properties and discuss observed nanointerferences with the assay. We propose alternative methods to avoid misleading results from nanoparticles and discuss the potential relevance of nanoparticle in vitro hemolytic properties to in vivo systems.
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Metrics
610
Total citations:
610
Citations from 2025:
62
(10.16%)
Cite this
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MLA
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GOST
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Dobrovolskaia M. et al. Method for Analysis of Nanoparticle Hemolytic Properties in Vitro // Nano Letters. 2008. Vol. 8. No. 8. pp. 2180-2187.
GOST all authors (up to 50)
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Dobrovolskaia M., Clogston J. D., Neun B. W., Hall J. B., Patri A. K., McNeil S. E. Method for Analysis of Nanoparticle Hemolytic Properties in Vitro // Nano Letters. 2008. Vol. 8. No. 8. pp. 2180-2187.
Cite this
RIS
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TY - JOUR
DO - 10.1021/nl0805615
UR - https://doi.org/10.1021/nl0805615
TI - Method for Analysis of Nanoparticle Hemolytic Properties in Vitro
T2 - Nano Letters
AU - Dobrovolskaia, Marina
AU - Clogston, Jeffrey D
AU - Neun, Barry W
AU - Hall, Jennifer B
AU - Patri, Anil K.
AU - McNeil, Scott E
PY - 2008
DA - 2008/07/08
PB - American Chemical Society (ACS)
SP - 2180-2187
IS - 8
VL - 8
PMID - 18605701
SN - 1530-6984
SN - 1530-6992
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2008_Dobrovolskaia,
author = {Marina Dobrovolskaia and Jeffrey D Clogston and Barry W Neun and Jennifer B Hall and Anil K. Patri and Scott E McNeil},
title = {Method for Analysis of Nanoparticle Hemolytic Properties in Vitro},
journal = {Nano Letters},
year = {2008},
volume = {8},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/nl0805615},
number = {8},
pages = {2180--2187},
doi = {10.1021/nl0805615}
}
Cite this
MLA
Copy
Dobrovolskaia, Marina, et al. “Method for Analysis of Nanoparticle Hemolytic Properties in Vitro.” Nano Letters, vol. 8, no. 8, Jul. 2008, pp. 2180-2187. https://doi.org/10.1021/nl0805615.