New Cytotoxic Alkaloids from the Wood of Vepris punctata from the Madagascar Rainforest
Chaturvedula V S Prakash
1
,
Jennifer K. Schilling
1
,
Allison L. Miller
1
,
Rabodo Andriantsiferana
1
,
Vincent E. Rasamison
1
,
1
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, and Centre National d'Application et des Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar
|
Publication type: Journal Article
Publication date: 2003-03-14
scimago Q1
wos Q1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
12713408
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
Bioassay-guided fractionation of a CH(2)Cl(2)/MeOH extract of the wood of Vepris punctata resulted in the isolation of three new furoquinoline alkaloids, 5-methoxymaculine (1), 5,8-dimethoxymaculine (2), and 4,5,6,7,8-pentamethoxyfuroquinoline (3), in addition to the four known alkaloids flindersiamine (4), kokusaginine (5), maculine (6), and skimmianine (7). The structures of the new alkaloids 1-3 were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. All the isolated compounds were tested against the A2780 human ovarian cancer cell line, and all seven alkaloids showed weak cytotoxic activity.
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31
Total citations:
31
Citations from 2025:
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GOST
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Prakash C. V. S. et al. New Cytotoxic Alkaloids from the Wood of Vepris punctata from the Madagascar Rainforest // Journal of Natural Products. 2003. Vol. 66. No. 4. pp. 532-534.
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Prakash C. V. S., Schilling J. K., Miller A. L., Andriantsiferana R., Rasamison V. E., Kingston D. New Cytotoxic Alkaloids from the Wood of Vepris punctata from the Madagascar Rainforest // Journal of Natural Products. 2003. Vol. 66. No. 4. pp. 532-534.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/np020578h
UR - https://doi.org/10.1021/np020578h
TI - New Cytotoxic Alkaloids from the Wood of Vepris punctata from the Madagascar Rainforest
T2 - Journal of Natural Products
AU - Prakash, Chaturvedula V S
AU - Schilling, Jennifer K.
AU - Miller, Allison L.
AU - Andriantsiferana, Rabodo
AU - Rasamison, Vincent E.
AU - Kingston, David
PY - 2003
DA - 2003/03/14
PB - American Chemical Society (ACS)
SP - 532-534
IS - 4
VL - 66
PMID - 12713408
SN - 0163-3864
SN - 1520-6025
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2003_Prakash,
author = {Chaturvedula V S Prakash and Jennifer K. Schilling and Allison L. Miller and Rabodo Andriantsiferana and Vincent E. Rasamison and David Kingston},
title = {New Cytotoxic Alkaloids from the Wood of Vepris punctata from the Madagascar Rainforest},
journal = {Journal of Natural Products},
year = {2003},
volume = {66},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/np020578h},
number = {4},
pages = {532--534},
doi = {10.1021/np020578h}
}
Cite this
MLA
Copy
Prakash, Chaturvedula V. S., et al. “New Cytotoxic Alkaloids from the Wood of Vepris punctata from the Madagascar Rainforest.” Journal of Natural Products, vol. 66, no. 4, Mar. 2003, pp. 532-534. https://doi.org/10.1021/np020578h.