Journal of Natural Products, volume 71, issue 7, pages 1146-1151
Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity
Publication type: Journal Article
Publication date: 2008-06-20
Journal:
Journal of Natural Products
Quartile SCImago
Q1
Quartile WOS
Q1
SJR: 0.802
CiteScore: 9.1
Impact factor: 3.3
ISSN: 01633864, 15206025
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
Bioassay-guided fractionation of the root wood of Zanthoxylum wutaiense led to the isolation of 11 new compounds, wutaiensol methyl ether (1), demethoxywutaiensol methyl ether (2), methyl wutaiensate (3), methyl 7-hydroxyanodendroate (4), methyl 7-methoxyanodendroate (5), wutaifuranol (6), 7-methoxywutaifuranol (7), 7-methoxywutaifuranal (8), methyl wutaifuranate (9), methyl 7-methoxybenzofuran-5-carboxylate (10), and wutaipyranol (12), together with another 37 known compounds, of which one, 7-methoxybenzofuran-5-carboxaldehyde (11), was not previously known as a plant constituent. The structures of these isolates were identified by means of spectroscopic analysis. Five of these isolates were found to be antitubercular constituents, namely, methyl 7-methoxyanodendroate (5), 7-methoxywutaifuranal (8), wutaiensal (13), dictamnine (14), and gamma-fagarine (15), which exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv, showing MIC values of 35, 35, 30, 30, and 30 microg/mL, respectively.
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Huang H. et al. Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity // Journal of Natural Products. 2008. Vol. 71. No. 7. pp. 1146-1151.
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Huang H., Ishikawa T., PENG C., Tsai I., Chen I. Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity // Journal of Natural Products. 2008. Vol. 71. No. 7. pp. 1146-1151.
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RIS
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TY - JOUR
DO - 10.1021/np700719e
UR - https://doi.org/10.1021/np700719e
TI - Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity
T2 - Journal of Natural Products
AU - Huang, Hung‐Yi
AU - Ishikawa, Tsutomu
AU - PENG, CHIEN-FANG
AU - Tsai, Ian-Lih
AU - Chen, Ih-Sheng
PY - 2008
DA - 2008/06/20
PB - American Chemical Society (ACS)
SP - 1146-1151
IS - 7
VL - 71
SN - 0163-3864
SN - 1520-6025
ER -
Cite this
BibTex
Copy
@article{2008_Huang,
author = {Hung‐Yi Huang and Tsutomu Ishikawa and CHIEN-FANG PENG and Ian-Lih Tsai and Ih-Sheng Chen},
title = {Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity},
journal = {Journal of Natural Products},
year = {2008},
volume = {71},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/np700719e},
number = {7},
pages = {1146--1151},
doi = {10.1021/np700719e}
}
Cite this
MLA
Copy
Huang, Hung‐Yi, et al. “Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity.” Journal of Natural Products, vol. 71, no. 7, Jun. 2008, pp. 1146-1151. https://doi.org/10.1021/np700719e.