Journal of Natural Products, volume 71, issue 7, pages 1146-1151
Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity
Publication type: Journal Article
Publication date: 2008-06-20
Journal:
Journal of Natural Products
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.1
ISSN: 01633864, 15206025
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
Bioassay-guided fractionation of the root wood of Zanthoxylum wutaiense led to the isolation of 11 new compounds, wutaiensol methyl ether (1), demethoxywutaiensol methyl ether (2), methyl wutaiensate (3), methyl 7-hydroxyanodendroate (4), methyl 7-methoxyanodendroate (5), wutaifuranol (6), 7-methoxywutaifuranol (7), 7-methoxywutaifuranal (8), methyl wutaifuranate (9), methyl 7-methoxybenzofuran-5-carboxylate (10), and wutaipyranol (12), together with another 37 known compounds, of which one, 7-methoxybenzofuran-5-carboxaldehyde (11), was not previously known as a plant constituent. The structures of these isolates were identified by means of spectroscopic analysis. Five of these isolates were found to be antitubercular constituents, namely, methyl 7-methoxyanodendroate (5), 7-methoxywutaifuranal (8), wutaiensal (13), dictamnine (14), and gamma-fagarine (15), which exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv, showing MIC values of 35, 35, 30, 30, and 30 microg/mL, respectively.
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Citations by publishers
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Huang H. et al. Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity // Journal of Natural Products. 2008. Vol. 71. No. 7. pp. 1146-1151.
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Huang H., Ishikawa T., PENG C., Tsai I., Chen I. Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity // Journal of Natural Products. 2008. Vol. 71. No. 7. pp. 1146-1151.
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TY - JOUR
DO - 10.1021/np700719e
UR - https://doi.org/10.1021/np700719e
TI - Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity
T2 - Journal of Natural Products
AU - Huang, Hung‐Yi
AU - Ishikawa, Tsutomu
AU - PENG, CHIEN-FANG
AU - Tsai, Ian-Lih
AU - Chen, Ih-Sheng
PY - 2008
DA - 2008/06/20 00:00:00
PB - American Chemical Society (ACS)
SP - 1146-1151
IS - 7
VL - 71
SN - 0163-3864
SN - 1520-6025
ER -
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@article{2008_Huang,
author = {Hung‐Yi Huang and Tsutomu Ishikawa and CHIEN-FANG PENG and Ian-Lih Tsai and Ih-Sheng Chen},
title = {Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity},
journal = {Journal of Natural Products},
year = {2008},
volume = {71},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/np700719e},
number = {7},
pages = {1146--1151},
doi = {10.1021/np700719e}
}
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Huang, Hung‐Yi, et al. “Constituents of the Root Wood of Zanthoxylum wutaiense with Antitubercular Activity.” Journal of Natural Products, vol. 71, no. 7, Jun. 2008, pp. 1146-1151. https://doi.org/10.1021/np700719e.