10-Oximeguanacone, the First Nitrogenated Acetogenin Derivative Found To Be a Potent Inhibitor of Mitochondrial Complex I
Publication type: Journal Article
Publication date: 1998-07-28
scimago Q1
wos Q1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
9722484
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
A new 10-keto bis-tetrahydrofuran acetogenin, guanacone (1), has been isolated from a cytotoxic extract of Annona aff. spraguei seeds. The 10-oximeguanacone derivative 1f is the first bioactive nitrogenated acetogenin found to be a very potent inhibitor of complex I. In addition, a SAR study of guanacone analogues is reported based on the titration of the NADH oxidase and NADH:ubiquinone oxidoreductase activities.
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Total citations:
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Citations from 2024:
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(4.17%)
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GOST
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Gallardo T. et al. 10-Oximeguanacone, the First Nitrogenated Acetogenin Derivative Found To Be a Potent Inhibitor of Mitochondrial Complex I // Journal of Natural Products. 1998. Vol. 61. No. 8. pp. 1001-1005.
GOST all authors (up to 50)
Copy
Gallardo T., Saez J., Granados H., Tormo J. R., Velez I. D., Brun N., Torres B., Cortes D. O. 10-Oximeguanacone, the First Nitrogenated Acetogenin Derivative Found To Be a Potent Inhibitor of Mitochondrial Complex I // Journal of Natural Products. 1998. Vol. 61. No. 8. pp. 1001-1005.
Cite this
RIS
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TY - JOUR
DO - 10.1021/np980079+
UR - https://doi.org/10.1021/np980079
TI - 10-Oximeguanacone, the First Nitrogenated Acetogenin Derivative Found To Be a Potent Inhibitor of Mitochondrial Complex I
T2 - Journal of Natural Products
AU - Gallardo, Teresa
AU - Saez, Jairo
AU - Granados, Hillmer
AU - Tormo, José R
AU - Velez, Ivan D.
AU - Brun, Nestor
AU - Torres, Beatriz
AU - Cortes, Diego Orbegozo
PY - 1998
DA - 1998/07/28
PB - American Chemical Society (ACS)
SP - 1001-1005
IS - 8
VL - 61
PMID - 9722484
SN - 0163-3864
SN - 1520-6025
ER -
Cite this
BibTex (up to 50 authors)
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@article{1998_Gallardo,
author = {Teresa Gallardo and Jairo Saez and Hillmer Granados and José R Tormo and Ivan D. Velez and Nestor Brun and Beatriz Torres and Diego Orbegozo Cortes},
title = {10-Oximeguanacone, the First Nitrogenated Acetogenin Derivative Found To Be a Potent Inhibitor of Mitochondrial Complex I},
journal = {Journal of Natural Products},
year = {1998},
volume = {61},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/np980079 },
number = {8},
pages = {1001--1005},
doi = {10.1021/np980079+}
}
Cite this
MLA
Copy
Gallardo, Teresa, et al. “10-Oximeguanacone, the First Nitrogenated Acetogenin Derivative Found To Be a Potent Inhibitor of Mitochondrial Complex I.” Journal of Natural Products, vol. 61, no. 8, Jul. 1998, pp. 1001-1005. https://doi.org/10.1021/np980079 .