Crystal structure of the S15–rRNA complex
Тип публикации: Journal Article
Дата публикации: 2000-04-01
PubMed ID:
10742169
Biochemistry
Genetics
Structural Biology
Краткое описание
In bacterial ribosomes, the small (30S) ribosomal subunit is composed of 16S rRNA and 21 distinct proteins. Ribosomal protein S15 is of particular interest because it binds primarily to 16S rRNA and is required for assembly of the small subunit and for intersubunit association, thus representing a key element in the assembly of a whole ribosome. Here we report the 2.8 Å resolution crystal structure of the highly conserved S15–rRNA complex. Protein S15 interacts in the minor groove with a G-U/G-C motif and a three-way junction. The latter is constrained by a conserved base triple and stacking interactions, and locked into place by magnesium ions and protein side chains, mainly through interactions with the unique three-dimensional geometry of the backbone. The present structure gives insights into the dual role of S15 in ribosome assembly and translational regulation.
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ГОСТ
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Dumas P. et al. Crystal structure of the S15–rRNA complex // Nature Structural Biology. 2000. Vol. 7. No. 4. pp. 273-277.
ГОСТ со всеми авторами (до 50)
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Dumas P., Nikulin A., Serganov A., Ennifar E., Tishchenko S., Nevskaya N., Shepard W., Portier C., Garber M., Ehresmann B., Ehresmann C., Nikonov S. Crystal structure of the S15–rRNA complex // Nature Structural Biology. 2000. Vol. 7. No. 4. pp. 273-277.
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TY - JOUR
DO - 10.1038/74028
UR - https://doi.org/10.1038/74028
TI - Crystal structure of the S15–rRNA complex
T2 - Nature Structural Biology
AU - Dumas, Philippe
AU - Nikulin, Alexei
AU - Serganov, Alexander
AU - Ennifar, Eric
AU - Tishchenko, Svetlana
AU - Nevskaya, Natalia
AU - Shepard, William
AU - Portier, Claude
AU - Garber, Maria
AU - Ehresmann, Bernard
AU - Ehresmann, Chantal
AU - Nikonov, Stanislav
PY - 2000
DA - 2000/04/01
PB - Springer Nature
SP - 273-277
IS - 4
VL - 7
PMID - 10742169
SN - 1072-8368
ER -
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@article{2000_Dumas,
author = {Philippe Dumas and Alexei Nikulin and Alexander Serganov and Eric Ennifar and Svetlana Tishchenko and Natalia Nevskaya and William Shepard and Claude Portier and Maria Garber and Bernard Ehresmann and Chantal Ehresmann and Stanislav Nikonov},
title = {Crystal structure of the S15–rRNA complex},
journal = {Nature Structural Biology},
year = {2000},
volume = {7},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1038/74028},
number = {4},
pages = {273--277},
doi = {10.1038/74028}
}
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MLA
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Dumas, Philippe, et al. “Crystal structure of the S15–rRNA complex.” Nature Structural Biology, vol. 7, no. 4, Apr. 2000, pp. 273-277. https://doi.org/10.1038/74028.