Laboratory of structural studies of the broadcasting apparatus

Regulation of gene expression by trans-encoded small regulatory RNAs (mrrnas) is a dynamically developing field of molecular biology. A large number of M. tuberculosis mrrnas have been identified using bioinformatics (comparative analysis) and genomics (RNA-seq, etc.), but only for some of them their functional significance has been reliably confirmed. In most bacteria, an important role in the functioning of mrRNA is played by so-called RNA chaperones - proteins that promote the interaction of mrRNA with mRNA due to their function to destroy (melt) the secondary structure of RNA molecules and ensure direct contact of two RNAs on the surface of the protein. The functioning of RNA chaperones in a number of gram-negative and gram-positive bacteria is being actively investigated, but their possible participation in the regulation of gene expression in mycobacteria has not been practically studied.