AMPK: a nutrient and energy sensor that maintains energy homeostasis
Publication type: Journal Article
Publication date: 2012-03-22
scimago Q1
wos Q1
SJR: 37.353
CiteScore: 150.9
Impact factor: 90.2
ISSN: 14710072, 14710080
DOI:
10.1038/nrm3311
PubMed ID:
22436748
Molecular Biology
Cell Biology
Abstract
AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by falling energy status, it promotes ATP production by increasing the activity or expression of proteins involved in catabolism while conserving ATP by switching off biosynthetic pathways. AMPK also regulates metabolic energy balance at the whole-body level. For example, it mediates the effects of agents acting on the hypothalamus that promote feeding and entrains circadian rhythms of metabolism and feeding behaviour. Finally, recent studies reveal that AMPK conserves ATP levels through the regulation of processes other than metabolism, such as the cell cycle and neuronal membrane excitability.
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GOST
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Hardie D. G., Ross F., HAWLEY S. A. AMPK: a nutrient and energy sensor that maintains energy homeostasis // Nature Reviews Molecular Cell Biology. 2012. Vol. 13. No. 4. pp. 251-262.
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Hardie D. G., Ross F., HAWLEY S. A. AMPK: a nutrient and energy sensor that maintains energy homeostasis // Nature Reviews Molecular Cell Biology. 2012. Vol. 13. No. 4. pp. 251-262.
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RIS
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TY - JOUR
DO - 10.1038/nrm3311
UR - https://doi.org/10.1038/nrm3311
TI - AMPK: a nutrient and energy sensor that maintains energy homeostasis
T2 - Nature Reviews Molecular Cell Biology
AU - Hardie, D. Grahame
AU - Ross, Fiona A.
AU - HAWLEY, Simon A.
PY - 2012
DA - 2012/03/22
PB - Springer Nature
SP - 251-262
IS - 4
VL - 13
PMID - 22436748
SN - 1471-0072
SN - 1471-0080
ER -
Cite this
BibTex (up to 50 authors)
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@article{2012_Hardie,
author = {D. Grahame Hardie and Fiona A. Ross and Simon A. HAWLEY},
title = {AMPK: a nutrient and energy sensor that maintains energy homeostasis},
journal = {Nature Reviews Molecular Cell Biology},
year = {2012},
volume = {13},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1038/nrm3311},
number = {4},
pages = {251--262},
doi = {10.1038/nrm3311}
}
Cite this
MLA
Copy
Hardie, D. Grahame, et al. “AMPK: a nutrient and energy sensor that maintains energy homeostasis.” Nature Reviews Molecular Cell Biology, vol. 13, no. 4, Mar. 2012, pp. 251-262. https://doi.org/10.1038/nrm3311.