Hypertension Research, volume 43, issue 10, pages 1068-1078
Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats
Plotnikov Mark B.
1, 2
,
Aliev Oleg I.
2
,
Shamanaev Aleksandr Y
2
,
Sidekhmenova Anastasia V.
2
,
Anishchenko Anna M.
2, 3
,
Fomina Tatiana I
2
,
Rydchenko Victoria S
4
,
Khlebnikov Andrei I.
5, 6
,
Anfinogenova Yana J
6, 7
,
Schepetkin Igor A.
6, 8
,
Atochin Dmitriy N
6, 9
8
Department of Microbiology and Immunology, Montana State University, Bozeman, USA
|
9
Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
|
Publication type: Journal Article
Publication date: 2020-05-07
Journal:
Hypertension Research
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.4
ISSN: 09169636, 13484214
Cardiology and Cardiovascular Medicine
Physiology
Internal Medicine
Abstract
c-Jun N-terminal kinases (JNKs) are involved in the myocardial and aortic remodeling, increased arterial tone, and arterial blood pressure elevation associated with hypertension. The aim of the present study was to investigate the antihypertensive effect of a new JNK inhibitor, 1H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt (IQ-1S), on spontaneously hypertensive rats (SHRs). Experiments were performed using normotensive Wistar-Kyoto (WKY) rats and SHRs. Experimental groups of SHRs received IQ-1S intragastrically for 6 weeks in daily doses of 5 and 50 mg/kg; experimental groups of WKY rats received 50 mg/kg IQ-1S according to the same regimen. The IQ-1S administration regimen induced decreases in systolic blood pressure, mean arterial blood pressure, total peripheral resistance, blood viscosity, hematocrit, myocardial cell cross-sectional area, and aortic wall thickness in SHRs vs untreated SHRs. There were no significant differences in systolic blood pressure values between the control and experimental groups of WKY rats during the treatment period. A concentration-dependent decrease in the tone of carotid arterial rings isolated from SHRs was observed after JNK inhibitor application in vitro. Application of the JNK inhibitor diminished endothelin-1 secretion by human umbilical vein endothelial cells in vitro. The main mechanisms of the antihypertensive effect of IQ-1S included the attenuation of blood viscosity due to decreased hematocrit, a vasodilatory effect on arterial smooth muscle cells, and a decrease in endothelin-1 production by endothelial cells.
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- We do not take into account publications that without a DOI.
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Plotnikov M. B. et al. Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats // Hypertension Research. 2020. Vol. 43. No. 10. pp. 1068-1078.
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Plotnikov M. B., Aliev O. I., Shamanaev A. Y., Sidekhmenova A. V., Anishchenko A. M., Fomina T. I., Rydchenko V. S., Khlebnikov A. I., Anfinogenova Y. J., Schepetkin I. A., Atochin D. N. Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats // Hypertension Research. 2020. Vol. 43. No. 10. pp. 1068-1078.
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TY - JOUR
DO - 10.1038/s41440-020-0446-9
UR - https://doi.org/10.1038%2Fs41440-020-0446-9
TI - Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats
T2 - Hypertension Research
AU - Plotnikov, Mark B.
AU - Aliev, Oleg I.
AU - Shamanaev, Aleksandr Y
AU - Sidekhmenova, Anastasia V.
AU - Anishchenko, Anna M.
AU - Fomina, Tatiana I
AU - Rydchenko, Victoria S
AU - Khlebnikov, Andrei I.
AU - Anfinogenova, Yana J
AU - Schepetkin, Igor A.
AU - Atochin, Dmitriy N
PY - 2020
DA - 2020/05/07 00:00:00
PB - Springer Nature
SP - 1068-1078
IS - 10
VL - 43
SN - 0916-9636
SN - 1348-4214
ER -
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@article{2020_Plotnikov,
author = {Mark B. Plotnikov and Oleg I. Aliev and Aleksandr Y Shamanaev and Anastasia V. Sidekhmenova and Anna M. Anishchenko and Tatiana I Fomina and Victoria S Rydchenko and Andrei I. Khlebnikov and Yana J Anfinogenova and Igor A. Schepetkin and Dmitriy N Atochin},
title = {Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats},
journal = {Hypertension Research},
year = {2020},
volume = {43},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1038%2Fs41440-020-0446-9},
number = {10},
pages = {1068--1078},
doi = {10.1038/s41440-020-0446-9}
}
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MLA
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Plotnikov, Mark B., et al. “Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats.” Hypertension Research, vol. 43, no. 10, May. 2020, pp. 1068-1078. https://doi.org/10.1038%2Fs41440-020-0446-9.