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Scientific Reports, volume 7, issue 1, publication number 12152

Pore formation in lipid membrane I: Continuous reversible trajectory from intact bilayer through hydrophobic defect to transversal pore

Akimov Sergey A ^{1, 2}

Volynsky Pavel E ³

Galimzyanov Timur R ^{1, 2}

Kuzmin Peter I ¹

Pavlov Konstantin V ^{1, 4}

Batishchev Oleg ^{1, 5}

Hide authors affiliations Show authors affiliations: 5 affiliations

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31/4 Leninskiy prospekt, Moscow, Russia |

National University of Science and Technology “MISiS”, 4 Leninskiy prospekt, Moscow, Russia |

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, Russia |

⁴

Federal Research and Clinical Center of Physical-Chemical Medicine, 1a Malaya Pirogovskaya, Moscow, Russia |

⁵

Moscow Institute of Physics and Technology, 9 Institutsky lane, Dolgoprudniy, Russia |

Publication type: Journal Article

Publication date: 2017-09-22

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/s41598-017-12127-7

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PubMed ID: 28939906

Multidisciplinary

Abstract

Lipid membranes serve as effective barriers allowing cells to maintain internal composition differing from that of extracellular medium. Membrane permeation, both natural and artificial, can take place via appearance of transversal pores. The rearrangements of lipids leading to pore formation in the intact membrane are not yet understood in details. We applied continuum elasticity theory to obtain continuous trajectory of pore formation and closure, and analyzed molecular dynamics trajectories of pre-formed pore reseal. We hypothesized that a transversal pore is preceded by a hydrophobic defect: intermediate structure spanning through the membrane, the side walls of which are partially aligned by lipid tails. This prediction was confirmed by our molecular dynamics simulations. Conversion of the hydrophobic defect into the hydrophilic pore required surmounting some energy barrier. A metastable state was found for the hydrophilic pore at the radius of a few nanometers. The dependence of the energy on radius was approximately quadratic for hydrophobic defect and small hydrophilic pore, while for large radii it depended on the radius linearly. The pore energy related to its perimeter, line tension, thus depends of the pore radius. Calculated values of the line tension for large pores were in quantitative agreement with available experimental data.

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Citations by journals

	1 2 3 4 5 6 7 8
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology	Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 8, 8.16% Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology 8 publications, 8.16%
Biophysical Journal	Biophysical Journal, 6, 6.12% Biophysical Journal 6 publications, 6.12%
Biochimica et Biophysica Acta - Biomembranes	Biochimica et Biophysica Acta - Biomembranes, 5, 5.1% Biochimica et Biophysica Acta - Biomembranes 5 publications, 5.1%
Journal of Chemical Theory and Computation	Journal of Chemical Theory and Computation, 4, 4.08% Journal of Chemical Theory and Computation 4 publications, 4.08%
Journal of Chemical Physics	Journal of Chemical Physics, 4, 4.08% Journal of Chemical Physics 4 publications, 4.08%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 4, 4.08% International Journal of Molecular Sciences 4 publications, 4.08%
Membranes	Membranes, 4, 4.08% Membranes 4 publications, 4.08%
Physical Review E	Physical Review E, 3, 3.06% Physical Review E 3 publications, 3.06%
Journal of Physical Chemistry B	Journal of Physical Chemistry B, 3, 3.06% Journal of Physical Chemistry B 3 publications, 3.06%
Langmuir	Langmuir, 3, 3.06% Langmuir 3 publications, 3.06%
Scientific Reports	Scientific Reports, 2, 2.04% Scientific Reports 2 publications, 2.04%
European Physical Journal E	European Physical Journal E, 2, 2.04% European Physical Journal E 2 publications, 2.04%
Bioelectrochemistry	Bioelectrochemistry, 2, 2.04% Bioelectrochemistry 2 publications, 2.04%
Chemistry and Physics of Lipids	Chemistry and Physics of Lipids, 2, 2.04% Chemistry and Physics of Lipids 2 publications, 2.04%
ACS Nano	ACS Nano, 2, 2.04% ACS Nano 2 publications, 2.04%
Soft Matter	Soft Matter, 2, 2.04% Soft Matter 2 publications, 2.04%
Journal of the American Chemical Society	Journal of the American Chemical Society, 2, 2.04% Journal of the American Chemical Society 2 publications, 2.04%
Physics of Fluids	Physics of Fluids, 1, 1.02% Physics of Fluids 1 publication, 1.02%
Physical Review Letters	Physical Review Letters, 1, 1.02% Physical Review Letters 1 publication, 1.02%
Journal of Cell Science	Journal of Cell Science, 1, 1.02% Journal of Cell Science 1 publication, 1.02%
Royal Society Open Science	Royal Society Open Science, 1, 1.02% Royal Society Open Science 1 publication, 1.02%
Molecules	Molecules, 1, 1.02% Molecules 1 publication, 1.02%
Viruses	Viruses, 1, 1.02% Viruses 1 publication, 1.02%
Food Engineering Reviews	Food Engineering Reviews, 1, 1.02% Food Engineering Reviews 1 publication, 1.02%
Nature Communications	Nature Communications, 1, 1.02% Nature Communications 1 publication, 1.02%
Biophysical Reviews	Biophysical Reviews, 1, 1.02% Biophysical Reviews 1 publication, 1.02%
Journal of Membrane Biology	Journal of Membrane Biology, 1, 1.02% Journal of Membrane Biology 1 publication, 1.02%
European Biophysics Journal	European Biophysics Journal, 1, 1.02% European Biophysics Journal 1 publication, 1.02%
Applied Microbiology and Biotechnology	Applied Microbiology and Biotechnology, 1, 1.02% Applied Microbiology and Biotechnology 1 publication, 1.02%
	1 2 3 4 5 6 7 8

Citations by publishers

	2 4 6 8 10 12 14 16 18
American Chemical Society (ACS)	American Chemical Society (ACS), 18, 18.37% American Chemical Society (ACS) 18 publications, 18.37%
Elsevier	Elsevier, 13, 13.27% Elsevier 13 publications, 13.27%
Springer Nature	Springer Nature, 11, 11.22% Springer Nature 11 publications, 11.22%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 10, 10.2% Multidisciplinary Digital Publishing Institute (MDPI) 10 publications, 10.2%
Pleiades Publishing	Pleiades Publishing, 10, 10.2% Pleiades Publishing 10 publications, 10.2%
Biophysical Society	Biophysical Society, 6, 6.12% Biophysical Society 6 publications, 6.12%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 6, 6.12% Royal Society of Chemistry (RSC) 6 publications, 6.12%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 5, 5.1% American Institute of Physics (AIP) 5 publications, 5.1%
American Physical Society (APS)	American Physical Society (APS), 4, 4.08% American Physical Society (APS) 4 publications, 4.08%
Wiley	Wiley, 3, 3.06% Wiley 3 publications, 3.06%
The Company of Biologists	The Company of Biologists, 1, 1.02% The Company of Biologists 1 publication, 1.02%
The Royal Society	The Royal Society, 1, 1.02% The Royal Society 1 publication, 1.02%
IOP Publishing	IOP Publishing, 1, 1.02% IOP Publishing 1 publication, 1.02%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 1.02% Public Library of Science (PLoS) 1 publication, 1.02%
American Society for Microbiology	American Society for Microbiology, 1, 1.02% American Society for Microbiology 1 publication, 1.02%
Taylor & Francis	Taylor & Francis, 1, 1.02% Taylor & Francis 1 publication, 1.02%
American Society for Cell Biology (ASCB)	American Society for Cell Biology (ASCB), 1, 1.02% American Society for Cell Biology (ASCB) 1 publication, 1.02%
	2 4 6 8 10 12 14 16 18

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Akimov S. A. et al. Pore formation in lipid membrane I: Continuous reversible trajectory from intact bilayer through hydrophobic defect to transversal pore // Scientific Reports. 2017. Vol. 7. No. 1. 12152

GOST all authors (up to 50) Copy

Akimov S. A., Volynsky P. E., Galimzyanov T. R., Kuzmin P. I., Pavlov K. V., Batishchev O. Pore formation in lipid membrane I: Continuous reversible trajectory from intact bilayer through hydrophobic defect to transversal pore // Scientific Reports. 2017. Vol. 7. No. 1. 12152

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41598-017-12127-7

UR - https://doi.org/10.1038%2Fs41598-017-12127-7

TI - Pore formation in lipid membrane I: Continuous reversible trajectory from intact bilayer through hydrophobic defect to transversal pore

T2 - Scientific Reports

AU - Akimov, Sergey A

AU - Volynsky, Pavel E

AU - Galimzyanov, Timur R

AU - Kuzmin, Peter I

AU - Pavlov, Konstantin V

AU - Batishchev, Oleg

PY - 2017

DA - 2017/09/22 00:00:00

PB - Springer Nature

IS - 1

VL - 7

PMID - 28939906

SN - 2045-2322

ER -

BibTex

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BibTex Copy

@article{2017_Akimov,

author = {Sergey A Akimov and Pavel E Volynsky and Timur R Galimzyanov and Peter I Kuzmin and Konstantin V Pavlov and Oleg Batishchev},

title = {Pore formation in lipid membrane I: Continuous reversible trajectory from intact bilayer through hydrophobic defect to transversal pore},

journal = {Scientific Reports},

year = {2017},

volume = {7},

publisher = {Springer Nature},

month = {sep},

url = {https://doi.org/10.1038%2Fs41598-017-12127-7},

number = {1},

doi = {10.1038/s41598-017-12127-7}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

Labs

Bioelectrochemistry Laboratory

Profiles

Batishchev, Oleg Vyacheslavovich