Targeting microbial biofilms: current and prospective therapeutic strategies
HYUN KOO
1
,
Raymond N Allan
2, 3
,
Robert P. Howlin
4, 5
,
Paul Stoodley
6, 7, 8
,
Luanne Hall-Stoodley
5, 6
Publication type: Journal Article
Publication date: 2017-09-25
scimago Q1
wos Q1
SJR: 13.861
CiteScore: 106.4
Impact factor: 103.3
ISSN: 17401526, 17401534
PubMed ID:
28944770
Microbiology
Infectious Diseases
General Immunology and Microbiology
Abstract
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections. The multifactorial nature of biofilm development and drug tolerance imposes great challenges for the use of conventional antimicrobials and indicates the need for multi-targeted or combinatorial therapies. In this Review, we focus on current therapeutic strategies and those under development that target vital structural and functional traits of microbial biofilms and drug tolerance mechanisms, including the extracellular matrix and dormant cells. We emphasize strategies that are supported by in vivo or ex vivo studies, highlight emerging biofilm-targeting technologies and provide a rationale for multi-targeted therapies aimed at disrupting the complex biofilm microenvironment.
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1.5k
Total citations:
1483
Citations from 2025:
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Cite this
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Cite this
GOST
Copy
KOO H. et al. Targeting microbial biofilms: current and prospective therapeutic strategies // Nature Reviews Microbiology. 2017. Vol. 15. No. 12. pp. 740-755.
GOST all authors (up to 50)
Copy
KOO H., Allan R. N., Howlin R. P., Stoodley P., Hall-Stoodley L. Targeting microbial biofilms: current and prospective therapeutic strategies // Nature Reviews Microbiology. 2017. Vol. 15. No. 12. pp. 740-755.
Cite this
RIS
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TY - JOUR
DO - 10.1038/nrmicro.2017.99
UR - https://doi.org/10.1038/nrmicro.2017.99
TI - Targeting microbial biofilms: current and prospective therapeutic strategies
T2 - Nature Reviews Microbiology
AU - KOO, HYUN
AU - Allan, Raymond N
AU - Howlin, Robert P.
AU - Stoodley, Paul
AU - Hall-Stoodley, Luanne
PY - 2017
DA - 2017/09/25
PB - Springer Nature
SP - 740-755
IS - 12
VL - 15
PMID - 28944770
SN - 1740-1526
SN - 1740-1534
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_KOO,
author = {HYUN KOO and Raymond N Allan and Robert P. Howlin and Paul Stoodley and Luanne Hall-Stoodley},
title = {Targeting microbial biofilms: current and prospective therapeutic strategies},
journal = {Nature Reviews Microbiology},
year = {2017},
volume = {15},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1038/nrmicro.2017.99},
number = {12},
pages = {740--755},
doi = {10.1038/nrmicro.2017.99}
}
Cite this
MLA
Copy
KOO, HYUN, et al. “Targeting microbial biofilms: current and prospective therapeutic strategies.” Nature Reviews Microbiology, vol. 15, no. 12, Sep. 2017, pp. 740-755. https://doi.org/10.1038/nrmicro.2017.99.