Open Access
Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity
Darya A Nedopekina
1
,
Rinat R Gubaidullin
1
,
V.N Odinokov
1
,
Polina V. Maximchik
2
,
Boris Zhivotovsky
2, 3
,
Yuriy P Belskii
4
,
Veniamin A Khazanov
4
,
Arina V Manuylova
4
,
Vladimir G. Gogvadze
2, 3
,
4
Innovative Pharmacology Research (IPHAR), 79/4 Elizarova, Tomsk 634021, Russian Federation
|
Publication type: Journal Article
Publication date: 2017-09-13
SJR: —
CiteScore: —
Impact factor: —
ISSN: 20402503, 20402511
PubMed ID:
30108714
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Pharmaceutical Science
Molecular Medicine
Abstract
Conjugation of native triterpenoids, namely, betulinic and ursolic acids, with a lypophilic triphenylphosphonium cation led to the dramatic enhancement, as compared to betulinic acid, of their ability to trigger the mitochondrial apoptosis pathway in various types of cancer cells.
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Metrics
71
Total citations:
71
Citations from 2025:
11
(15.49%)
Cite this
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RIS |
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MLA
Cite this
GOST
Copy
Nedopekina D. A. et al. Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity // MedChemComm. 2017. Vol. 8. No. 10. pp. 1934-1945.
GOST all authors (up to 50)
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Nedopekina D. A., Gubaidullin R. R., Odinokov V., Maximchik P. V., Zhivotovsky B., Belskii Y. P., Khazanov V. A., Manuylova A. V., Gogvadze V. G., Spivak A. V. Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity // MedChemComm. 2017. Vol. 8. No. 10. pp. 1934-1945.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/C7MD00248C
UR - https://doi.org/10.1039/C7MD00248C
TI - Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity
T2 - MedChemComm
AU - Nedopekina, Darya A
AU - Gubaidullin, Rinat R
AU - Odinokov, V.N
AU - Maximchik, Polina V.
AU - Zhivotovsky, Boris
AU - Belskii, Yuriy P
AU - Khazanov, Veniamin A
AU - Manuylova, Arina V
AU - Gogvadze, Vladimir G.
AU - Spivak, A. V.
PY - 2017
DA - 2017/09/13
PB - Royal Society of Chemistry (RSC)
SP - 1934-1945
IS - 10
VL - 8
PMID - 30108714
SN - 2040-2503
SN - 2040-2511
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Nedopekina,
author = {Darya A Nedopekina and Rinat R Gubaidullin and V.N Odinokov and Polina V. Maximchik and Boris Zhivotovsky and Yuriy P Belskii and Veniamin A Khazanov and Arina V Manuylova and Vladimir G. Gogvadze and A. V. Spivak},
title = {Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity},
journal = {MedChemComm},
year = {2017},
volume = {8},
publisher = {Royal Society of Chemistry (RSC)},
month = {sep},
url = {https://doi.org/10.1039/C7MD00248C},
number = {10},
pages = {1934--1945},
doi = {10.1039/C7MD00248C}
}
Cite this
MLA
Copy
Nedopekina, Darya A., et al. “Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity.” MedChemComm, vol. 8, no. 10, Sep. 2017, pp. 1934-1945. https://doi.org/10.1039/C7MD00248C.
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